KRR1

KRR1

Identifiers

KRR1, HRB2, RIP-1, small subunit processome component homolog, KRR1 small subunit processome component homolog

External IDs

OMIM: 612817; MGI: 1289274; GeneCards: KRR1

Gene location (Human)

Chr.	Chromosome 12 (human)

Band	12q21.2	Start	75,490,863 bp
Band	12q21.2	End	75,511,636 bp

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10 D1- D2\|10 59.97 cM	Start	111,808,569 bp
Band	10 D1- D2\|10 59.97 cM	End	111,824,337 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

Achilles tendon

oocyte

secondary oocyte

caput epididymis

gonad

tail of epididymis

mucosa of paranasal sinus

corpus epididymis

tonsil

islet of Langerhans

Top expressed in

primitive streak

Paneth cell

genital tubercle

tail of embryo

fossa

abdominal wall

retinal pigment epithelium

condyle

ciliary body

vas deferens

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding nucleic acid binding RNA binding
Cellular component	cytoplasm small-subunit processome nucleolus membrane nucleus intercellular bridge nucleoplasm
Biological process	ribosome biogenesis maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rRNA processing
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11103


52705


ENSG00000111615


ENSMUSG00000063334


Q13601


Q8BGA5

RefSeq (mRNA)


NM_007043


NM_178610

RefSeq (protein)


NP_008974


NP_848725

Location (UCSC)

Chr 12: 75.49 – 75.51 Mb

Chr 10: 111.81 – 111.82 Mb

PubMed search

View/Edit Human

View/Edit Mouse

KRR1 small subunit processome component homolog is a protein that in humans is encoded by the KRR1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111615 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000063334 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Epplen C, Epplen JT (Feb 1994). "Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes". Hum Genet. 93 (1): 35–41. doi:10.1007/BF00218910. PMID 7505766. S2CID 22998633.
↑ Sasaki T, Toh-E A, Kikuchi Y (Oct 2000). "Yeast Krr1p Physically and Functionally Interacts with a Novel Essential Kri1p, and Both Proteins Are Required for 40S Ribosome Biogenesis in the Nucleolus". Mol Cell Biol. 20 (21): 7971–9. doi:10.1128/MCB.20.21.7971-7979.2000. PMC 86407. PMID 11027267.
↑ Chan HY, Brogna S, O'Kane CJ (May 2001). "Dribble, the Drosophila KRR1p Homologue, Is Involved in rRNA Processing". Mol Biol Cell. 12 (5): 1409–19. doi:10.1091/mbc.12.5.1409. PMC 34593. PMID 11359931.
↑ Gromadka R, Kaniak A, Slonimski PP, Rytka J (Aug 1996). "A novel cross-phylum family of proteins comprises a KRR1 (YCL059c) gene which is essential for viability of Saccharomyces cerevisiae cells". Gene. 171 (1): 27–32. doi:10.1016/0378-1119(96)00024-8. PMID 8675026.
↑ "Entrez Gene: KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast)".

Further reading

Muthumani K, Choo AY, Premkumar A, et al. (2006). "Human immunodeficiency virus type 1 (HIV-1) Vpr-regulated cell death: insights into mechanism". Cell Death Differ. 12 (Suppl 1): 962–70. doi:10.1038/sj.cdd.4401583. PMID 15832179.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional Proteomic Analysis of Human Nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Micheau O, Tschopp J (2003). "Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes" (PDF). Cell. 114 (2): 181–90. doi:10.1016/S0092-8674(03)00521-X. PMID 12887920. S2CID 17145731.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Bernstein KA, Gallagher JE, Mitchell BM, et al. (2005). "The Small-Subunit Processome Is a Ribosome Assembly Intermediate". Eukaryotic Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer". Mamm. Genome. 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. S2CID 69278.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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