LANCL1

LANCL1
Identifiers
Aliases	LANCL1, GPR69A, p40, LanC like 1
External IDs	OMIM: 604155; MGI: 1336997; GeneCards: LANCL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3E6U, 3E73
Enzyme activity
Gene location (Human)
Chr.	Chromosome 2 (human)
End	210,477,652 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	67,078,031 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; corpus callosum; ; inferior ganglion of vagus nerve; ; subthalamic nucleus; ; inferior olivary nucleus; ; Brodmann area 46; ; pars reticulata; ; postcentral gyrus; ; external globus pallidus; ; lateral nuclear group of thalamus;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; corneal stroma; ; primary oocyte; ; facial motor nucleus; ; anterior horn of spinal cord; ; barrel cortex; ; cingulate gyrus; ; olfactory tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	SH3 domain binding; low-density lipoprotein particle receptor binding; zinc ion binding; protein binding; G protein-coupled receptor activity; metal ion binding; glutathione binding; catalytic activity; glutathione transferase activity; transferase activity;
Cellular component	cytoplasm; integral component of plasma membrane; membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; regulation of neuron apoptotic process; regulation of oxidative stress-induced neuron death;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10314
	14768
	ENSG00000115365
	ENSMUSG00000026000
	O43813
	O89112
	NM_001136574; NM_001136575; NM_006055
	NM_001190984; NM_001190985; NM_021295
	NP_001130046; NP_001130047; NP_006046
	NP_001177913; NP_001177914; NP_067270
	Wikidata
View/Edit Human	View/Edit Mouse

LanC like 1 is a protein that in humans is encoded by the LANCL1 gene.

Function

This gene encodes a loosely associated peripheral membrane protein related to the LanC family of bacterial membrane-associated proteins involved in the biosynthesis of antimicrobial peptides. This protein may play a role as a peptide-modifying enzyme component in eukaryotic cells. Previously considered a member of the G-protein-coupled receptor superfamily, this protein is now in the LanC family. Multiple alternatively spliced variants, encoding the same protein, have been identified.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115365 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026000 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: LanC like 1". Retrieved 2016-04-20.

LANCL1

Function

References

Further reading