LEO1

LEO1

Identifiers

LEO1, RDL, LEO1 homolog, Paf1/RNA polymerase II complex component

External IDs

OMIM: 610507; MGI: 2685031; GeneCards: LEO1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4M6T

Gene location (Human)

Chr.	Chromosome 15 (human)

Band	15q21.2	Start	51,938,025 bp
Band	15q21.2	End	51,971,778 bp

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)

Band	9\|9 D	Start	75,348,806 bp
Band	9\|9 D	End	75,373,714 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

tendon of biceps brachii

ventricular zone

mucosa of transverse colon

ganglionic eminence

oocyte

rectum

islet of Langerhans

Achilles tendon

internal globus pallidus

secondary oocyte

Top expressed in

otic vesicle

tail of embryo

genital tubercle

neural layer of retina

zygote

morula

hand

blastocyst

embryo

ventricular zone

More reference expression data


More reference expression data

Gene ontology
Molecular function	RNA polymerase II C-terminal domain phosphoserine binding protein binding
Cellular component	nucleus centrosome Cdc73/Paf1 complex nucleoplasm fibrillar center
Biological process	negative regulation of myeloid cell differentiation positive regulation of mRNA 3'-end processing mRNA polyadenylation endodermal cell fate commitment Wnt signaling pathway histone H2B ubiquitination stem cell population maintenance regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated histone monoubiquitination positive regulation of transcription elongation from RNA polymerase II promoter histone modification beta-catenin-TCF complex assembly transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


123169


235497


ENSG00000166477


ENSMUSG00000042487


Q8WVC0


Q5XJE5

RefSeq (mRNA)


NM_001286430 NM_138792 NM_001323903 NM_001323904


NM_001006122 NM_001039522

RefSeq (protein)


NP_001273359 NP_001310832 NP_001310833 NP_620147


NP_001034611

Location (UCSC)

Chr 15: 51.94 – 51.97 Mb

Chr 9: 75.35 – 75.37 Mb

PubMed search

View/Edit Human

View/Edit Mouse

RNA polymerase-associated protein LEO1 is an enzyme that in humans is encoded by the LEO1 gene. This protein is part of the PAF1 complex.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166477 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000042487 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, Resau JH, Meyerson M (Jan 2005). "The Parafibromin Tumor Suppressor Protein Is Part of a Human Paf1 Complex". Mol Cell Biol. 25 (2): 612–20. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
1 2 "Entrez Gene: LEO1 Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)".

Further reading

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhao L, Tong T, Zhang Z (2005). "Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts". FASEB J. 19 (6): 521–32. doi:10.1096/fj.04-2689com. PMID 15791002. S2CID 6839737.
Mosimann C, Hausmann G, Basler K (2006). "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo". Cell. 125 (2): 327–41. doi:10.1016/j.cell.2006.01.053. PMID 16630820.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.