LETM2

LETM2
Identifiers
Aliases	LETM2, leucine zipper and EF-hand containing transmembrane protein 2, SLC55A2
External IDs	MGI: 2444979; GeneCards: LETM2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	38,409,527 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	26,087,598 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; secondary oocyte; ; islet of Langerhans; ; Descending thoracic aorta; ; anterior pituitary; ; stromal cell of endometrium; ; testicle;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; neural layer of retina; ; granulocyte; ; zygote; ; muscle of thigh; ; cerebellar cortex; ; otolith organ; ; facial motor nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	ribosome binding;
Cellular component	membrane; mitochondrion; integral component of membrane; mitochondrial inner membrane;
Biological process	cellular metal ion homeostasis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	137994
	270035
	ENSG00000165046
	ENSMUSG00000037363
	Q2VYF4
	Q7TNU7
NM_001199659; NM_001199660; NM_001286787; NM_001286819; NM_001286821;
	NM_144652; NM_001330515; NM_001363204; NM_001363205
	NM_173012; NM_001364069; NM_001364070; NM_001364071
NP_001186588; NP_001186589; NP_001273716; NP_001273748; NP_001273750;
	NP_001317444; NP_653253; NP_001350133; NP_001350134
	NP_766600; NP_001350998; NP_001350999; NP_001351000
	Wikidata
View/Edit Human	View/Edit Mouse

LETM2, also known as Leucine Zipper And EF-Hand Containing Transmembrane Protein 2, is a protein that in humans is encoded by the LETM2 gene. LETM2 is a mitochondrial membrane transporter that belongs to solute carrier family 55. It is predicted to be involved in mitochondrial calcium ion transmembrane transport and mitochondrion organization. Diseases associated with LETM2 include Wolf-Hirschhorn Syndrome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165046 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037363 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "LETM2 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.
↑ "LETM2 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165046 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037363 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "LETM2 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.

[6] "LETM2 Gene - GeneCards". www.genecards.org. Retrieved 2026-10-05.