LGI2

LGI2

Identifiers

LGI2, LGIL2, leucine-rich repeat LGI family member 2, leucine rich repeat LGI family member 2

External IDs

OMIM: 608301; MGI: 2180196; GeneCards: LGI2

Gene location (Human)

Chr.	Chromosome 4 (human)

Band	4p15.2	Start	24,998,847 bp
Band	4p15.2	End	25,030,946 bp

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)

Band	5\|5 C1	Start	52,690,859 bp
Band	5\|5 C1	End	52,723,804 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

smooth muscle tissue

left uterine tube

gastric mucosa

tibial nerve

right coronary artery

left coronary artery

gallbladder

appendix

prefrontal cortex

body of uterus

Top expressed in

conjunctival fornix

iris

deep cerebellar nuclei

pontine nuclei

medial vestibular nucleus

inferior colliculi

substantia nigra

facial motor nucleus

ciliary body

dorsal tegmental nucleus

More reference expression data


More reference expression data

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


55203


246316


ENSG00000153012


ENSMUSG00000039252


Q8N0V4


Q8K4Z0

RefSeq (mRNA)


NM_018176


NM_144945 NM_001310604

RefSeq (protein)


NP_060646


NP_001297533 NP_659194

Location (UCSC)

Chr 4: 25 – 25.03 Mb

Chr 5: 52.69 – 52.72 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Leucine-rich repeat LGI family member 2 is a protein that in humans is encoded by the LGI2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000153012 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039252 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gu W, Wevers A, Schroder H, Grzeschik KH, Derst C, Brodtkorb E, de Vos R, Steinlein OK (May 2002). "The LGI1 gene involved in lateral temporal lobe epilepsy belongs to a new subfamily of leucine-rich repeat proteins". FEBS Lett. 519 (1–3): 71–6. doi:10.1016/S0014-5793(02)02713-8. PMID 12023020. S2CID 41639083.
↑ Gu W, Gibert Y, Wirth T, Elischer A, Bloch W, Meyer A, Steinlein OK, Begemann G (Oct 2005). "Using gene-history and expression analyses to assess the involvement of LGI genes in human disorders". Mol Biol Evol. 22 (11): 2209–16. doi:10.1093/molbev/msi214. hdl:10536/DRO/DU:30063551. PMID 16014869.
↑ "Entrez Gene: LGI2 leucine-rich repeat LGI family, member 2".

Further reading

Staub E, Pérez-Tur J, Siebert R, et al. (2002). "The novel EPTP repeat defines a superfamily of proteins implicated in epileptic disorders". Trends Biochem. Sci. 27 (9): 441–4. doi:10.1016/S0968-0004(02)02163-1. PMID 12217514.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Kikuno R, Ohara O (2002). "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins". DNA Res. 8 (4): 179–87. doi:10.1093/dnares/8.4.179. PMID 11572484.
Scheel H, Tomiuk S, Hofmann K (2003). "A common protein interaction domain links two recently identified epilepsy genes". Hum. Mol. Genet. 11 (15): 1757–62. doi:10.1093/hmg/11.15.1757. PMID 12095917.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.

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