LILRA1

LILRA1

Identifiers

LILRA1, CD85I, LIR-6, LIR6, leukocyte immunoglobulin like receptor A1

External IDs

OMIM: 604810; GeneCards: LILRA1

Gene location (Human)

Chr.	Chromosome 19 (human)

Band	19q13.42	Start	54,593,582 bp
Band	19q13.42	End	54,602,381 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

monocyte

granulocyte

blood

spleen

appendix

testicle

bone marrow

bone marrow cell

right lung

upper lobe of left lung

n/a

More reference expression data

n/a

Gene ontology
Molecular function	antigen binding transmembrane signaling receptor activity
Cellular component	integral component of membrane plasma membrane membrane
Biological process	defense response cell surface receptor signaling pathway adaptive immune response regulation of immune response immune system process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11024


n/a


ENSG00000275525 ENSG00000277398 ENSG00000104974 ENSG00000274935


n/a


O75019


n/a

RefSeq (mRNA)


NM_001278318 NM_001278319 NM_006863


n/a

RefSeq (protein)


NP_001265247 NP_001265248 NP_006854


n/a

Location (UCSC)

Chr 19: 54.59 – 54.6 Mb

n/a

PubMed search

n/a

View/Edit Human

Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 is a protein that in humans is encoded by the LILRA1 gene.

References

1 2 3 ENSG00000277398, ENSG00000104974, ENSG00000274935 GRCh38: Ensembl release 89: ENSG00000275525, ENSG00000277398, ENSG00000104974, ENSG00000274935 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1".

Further reading

Allen RL, Raine T, Haude A, Trowsdale J, Wilson MJ (November 2001). "Leukocyte receptor complex-encoded immunomodulatory receptors show differing specificity for alternative HLA-B27 structures". Journal of Immunology. 167 (10): 5543–7. doi:10.4049/jimmunol.167.10.5543. PMID 11698424.
Tedla N, Lee CW, Borges L, Geczy CL, Arm JP (February 2008). "Differential expression of leukocyte immunoglobulin-like receptors on cord-blood-derived human mast cell progenitors and mature mast cells". Journal of Leukocyte Biology. 83 (2): 334–43. doi:10.1189/jlb.0507314. PMID 17998301. S2CID 17379108.
Wilson MJ, Torkar M, Haude A, Milne S, Jones T, Sheer D, Beck S, Trowsdale J (April 2000). "Plasticity in the organization and sequences of human KIR/ILT gene families". Proceedings of the National Academy of Sciences of the United States of America. 97 (9): 4778–83. Bibcode:2000PNAS...97.4778W. doi:10.1073/pnas.080588597. PMC 18309. PMID 10781084.
Brown D, Trowsdale J, Allen R (September 2004). "The LILR family: modulators of innate and adaptive immune pathways in health and disease". Tissue Antigens. 64 (3): 215–25. doi:10.1111/j.0001-2815.2004.00290.x. PMID 15304001.
Tedla N, An H, Borges L, Vollmer-Conna U, Bryant K, Geczy C, McNeil HP (April 2011). "Expression of activating and inhibitory leukocyte immunoglobulin-like receptors in rheumatoid synovium: correlations to disease activity". Tissue Antigens. 77 (4): 305–16. doi:10.1111/j.1399-0039.2011.01633.x. PMID 21388353.
Pilsbury LE, Allen RL, Vordermeier M (2010). "Modulation of Toll-like receptor activity by leukocyte Ig-like receptors and their effects during bacterial infection". Mediators of Inflammation. 2010 536478. doi:10.1155/2010/536478. PMC 2903975. PMID 20634939.
Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (December 1997). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". Journal of Immunology. 159 (11): 5192–6. doi:10.4049/jimmunol.159.11.5192. PMID 9548455.
Ryu M, Chen Y, Qi J, Liu J, Fan Z, Nam G, Shi Y, Cheng H, Gao GF (April 2011). Kanellopoulos J (ed.). "LILRA3 binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1/LILRB2: structural evidence". PLOS ONE. 6 (4) e19245. Bibcode:2011PLoSO...619245R. doi:10.1371/journal.pone.0019245. PMC 3084784. PMID 21559424.
Wang KS, Liu X, Aragam N, Mullersman JE, Jian X, Pan Y, Liu Y (February 2012). "Polymorphisms in ABLIM1 are associated with personality traits and alcohol dependence". Journal of Molecular Neuroscience. 46 (2): 265–71. doi:10.1007/s12031-011-9530-6. PMID 21547531. S2CID 6276103.

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