LMLN

LMLN
Identifiers
Aliases	LMLN, GP63, INV, IX14, MSP, leishmanolysin like peptidase, LMNL1
External IDs	OMIM: 609380; MGI: 2444736; GeneCards: LMLN
Gene location (Human)
Chr.	Chromosome 3 (human)
End	198,043,720 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	32,948,065 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; corpus epididymis; ; secondary oocyte; ; caput epididymis; ; mucosa of paranasal sinus; ; Brodmann area 23; ; tail of epididymis; ; pancreatic ductal cell; ; sperm; ; middle temporal gyrus;
	Top expressed in
	otolith organ; ; utricle; ; neural layer of retina; ; substantia nigra; ; spermatocyte; ; trigeminal ganglion; ; Rostral migratory stream; ; ventromedial nucleus; ; cumulus cell; ; retinal pigment epithelium;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	lipid droplet; membrane; focal adhesion; cytoplasm; cytosol;
Biological process	cell cycle; cell adhesion; proteolysis; cell division;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	89782
	239833
	ENSG00000185621
	ENSMUSG00000022802
	Q96KR4
	Q8BMN4
	NM_001136049; NM_033029
	NM_172823
	NP_001129521; NP_149018
	NP_766411
	Wikidata
View/Edit Human	View/Edit Mouse

Leishmanolysin-like (metallopeptidase M8 family) is a protein that in humans is encoded by the LMLN gene.

Function

This gene encodes a zinc-metallopeptidase. The encoded protein may play a role in cell migration and invasion. Studies of a similar protein in Drosophila indicate a potential role in mitotic progression. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009].

Clinical Significance

Clinical information about the LMLN is limited to the aforementioned functional associations, rather than constituting a defined disease spectrum. No pathogenic variants linked to this gene have yet been identified, however, scientific literature suggests a role for it in a cell invasion and migration processes. Currently there are no specific treatments that target this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000185621 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022802 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Leishmanolysin-like (metallopeptidase M8 family)".
↑ "Checking your browser - reCAPTCHA". www.ncbi.nlm.nih.gov. Retrieved 2026-10-19.
↑ https://www.genecards.org/card/LMLN

Cobbe N, Marshall KM, Gururaja Rao S, Chang CW, Di Cara F, Duca E, Vass S, Kassan A, Heck MM (September 2009). "The conserved metalloprotease invadolysin localizes to the surface of lipid droplets". Journal of Cell Science. 122 (Pt 18): 3414–23. doi:10.1242/jcs.044610. PMC 2736869. PMID 19706689.
McHugh B, Krause SA, Yu B, Deans AM, Heasman S, McLaughlin P, Heck MM (November 2004). "Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration". The Journal of Cell Biology. 167 (4): 673–86. doi:10.1083/jcb.200405155. PMC 2172566. PMID 15557119.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000185621 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Leishmanolysin-like (metallopeptidase M8 family)".

[6] "Checking your browser - reCAPTCHA". www.ncbi.nlm.nih.gov. Retrieved 2026-10-19.

[7] ttps://www.genecards.org/card/LMLN

LMLN

Function

Clinical Significance

References

Further reading