LMO4

LMO4
Identifiers
Aliases	LMO4, LIM domain only 4
External IDs	OMIM: 603129; MGI: 109360; GeneCards: LMO4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4Z
Gene location (Human)
Chr.	Chromosome 1 (human)
End	87,348,923 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	143,910,981 bp
RNA expression pattern
	Top expressed in
	dorsolateral prefrontal cortex; ; prefrontal cortex; ; Brodmann area 46; ; superior frontal gyrus; ; parietal lobe; ; postcentral gyrus; ; Brodmann area 9; ; frontal pole; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	granulocyte; ; genital tubercle; ; cingulate gyrus; ; superior frontal gyrus; ; visual cortex; ; primary motor cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; corneal stroma;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; protein binding; cis-regulatory region sequence-specific DNA binding; transcription factor binding;
Cellular component	transcription regulator complex; cell leading edge;
Biological process	regulation of transcription, DNA-templated; ventricular septum development; spinal cord association neuron differentiation; thymus development; negative regulation of protein-containing complex assembly; transcription, DNA-templated; ventral spinal cord interneuron differentiation; regulation of cell activation; spinal cord motor neuron differentiation; regulation of cell fate specification; positive regulation of transcription by RNA polymerase II; neural tube closure; transcription by RNA polymerase II; positive regulation of kinase activity; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8543
	16911
	ENSG00000143013
	ENSMUSG00000028266
	P61968
	P61969
	NM_006769; NM_001369491
	NM_001161769; NM_001161770; NM_010723
	NP_006760; NP_001356420
	NP_001155241; NP_001155242; NP_034853
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.

LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT motifs in the 3' region. A variant transcript missing a portion of the 5' region has been identified but cannot be confirmed because of the GC-rich nature of the region.

Clinical significance

LMO4 has garnered significant attention for its involvement in cancer, particularly breast cancer. It is overexpressed in a substantial percentage of primary breast carcinomas. Studies have shown that LMO4 can promote the proliferation of mammary epithelial cells, inhibit their differentiation, and enhance cell invasion and motility, all of which are hallmarks of cancer progression.

Interactions

LMO4 has been shown to interact with LDB1, RBBP8 and BRCA1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143013 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028266 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: LMO4 LIM domain only 4".
↑ Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R (November 2005). "Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein". Cancer Research. 65 (22): 10594–10601. doi:10.1158/0008-5472.CAN-05-2268. PMID 16288053.
↑ Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, et al. (May 2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7659–7664. doi:10.1073/pnas.0502990102. PMC 1140463. PMID 15897450.
1 2 3 Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". International Journal of Cancer. 107 (1): 155–158. doi:10.1002/ijc.11343. PMID 12925972.
↑ Deane JE, Mackay JP, Kwan AH, Sum EY, Visvader JE, Matthews JM (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". The EMBO Journal. 22 (9): 2224–2233. doi:10.1093/emboj/cdg196. PMC 156068. PMID 12727888.
1 2 Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, et al. (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". The Journal of Biological Chemistry. 277 (10): 7849–7856. doi:10.1074/jbc.M110603200. PMID 11751867.

Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis". Proceedings of the National Academy of Sciences of the United States of America. 95 (19): 11257–11262. Bibcode:1998PNAS...9511257K. doi:10.1073/pnas.95.19.11257. PMC 21629. PMID 9736723.
Racevskis J, Dill A, Sparano JA, Ruan H (1999). "Molecular cloning of LMO41, a new human LIM domain gene". Biochimica et Biophysica Acta. 1445 (1): 148–153. doi:10.1016/s0167-4781(99)00037-8. PMID 10209267.
Tse E, Grutz G, Garner AA, Ramsey Y, Carter NP, Copeland N, et al. (November 1999). "Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping". Mammalian Genome. 10 (11): 1089–1094. doi:10.1007/s003359901167. PMID 10556429. S2CID 19479121.
Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex". Journal of Biomolecular NMR. 23 (2): 165–166. doi:10.1023/A:1016363414644. PMID 12153047. S2CID 30891765.
Vu D, Marin P, Walzer C, Cathieni MM, Bianchi EN, Saïdji F, et al. (July 2003). "Transcription regulator LMO4 interferes with neuritogenesis in human SH-SY5Y neuroblastoma cells". Brain Research. Molecular Brain Research. 115 (2): 93–103. doi:10.1016/S0169-328X(03)00119-0. PMID 12877980.
Manetopoulos C, Hansson A, Karlsson J, Jönsson JI, Axelson H (August 2003). "The LIM-only protein LMO4 modulates the transcriptional activity of HEN1". Biochemical and Biophysical Research Communications. 307 (4): 891–899. doi:10.1016/S0006-291X(03)01298-1. PMID 12878195.
Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, et al. (July 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Novotny-Diermayr V, Lin B, Gu L, Cao X (2005). "Modulation of the interleukin-6 receptor subunit glycoprotein 130 complex and its signaling by LMO4 interaction". The Journal of Biological Chemistry. 280 (13): 12747–12757. doi:10.1074/jbc.M500175200. PMID 15677447.
Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, et al. (June 2005). "Early asymmetry of gene transcription in embryonic human left and right cerebral cortex". Science. 308 (5729). New York, N.Y.: 1794–1798. Bibcode:2005Sci...308.1794S. doi:10.1126/science.1110324. PMC 2756725. PMID 15894532.
Jeffries CM, Graham SC, Stokes PH, Collyer CA, Guss JM, Matthews JM (November 2006). "Stabilization of a binary protein complex by intein-mediated cyclization". Protein Science. 15 (11): 2612–2618. doi:10.1110/ps.062377006. PMC 2242402. PMID 17001033.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143013 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028266 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: LMO4 LIM domain only 4".

[6] Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R (November 2005). "Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein". Cancer Research. 65 (22): 10594–10601. doi:10.1158/0008-5472.CAN-05-2268. PMID 16288053.

[7] Sum EY, Segara D, Duscio B, Bath ML, Field AS, Sutherland RL, et al. (May 2005). "Overexpression of LMO4 induces mammary hyperplasia, promotes cell invasion, and is a predictor of poor outcome in breast cancer". Proceedings of the National Academy of Sciences of the United States of America. 102 (21): 7659–7664. doi:10.1073/pnas.0502990102. PMC 1140463. PMID 15897450.

[Sutherland_2003-8] 1 2 3 Sutherland KD, Visvader JE, Choong DY, Sum EY, Lindeman GJ, Campbell IG (October 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". International Journal of Cancer. 107 (1): 155–158. doi:10.1002/ijc.11343. PMID 12925972.

[Deane_2003-9] Deane JE, Mackay JP, Kwan AH, Sum EY, Visvader JE, Matthews JM (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". The EMBO Journal. 22 (9): 2224–2233. doi:10.1093/emboj/cdg196. PMC 156068. PMID 12727888.

[Sum_2002-10] 1 2 Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, et al. (March 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". The Journal of Biological Chemistry. 277 (10): 7849–7856. doi:10.1074/jbc.M110603200. PMID 11751867.

LMO4

Clinical significance

Interactions

References

Further reading