Layilin

LAYN

Identifiers

LAYN, Layilin

External IDs

MGI: 2685357; GeneCards: LAYN

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11q23.1	Start	111,540,280 bp
Band	11q23.1	End	111,561,745 bp

Gene location (Mouse)

Chr.	Chromosome 9 (mouse)

Band	9\|9 A5.3	Start	50,965,940 bp
Band	9\|9 A5.3	End	50,988,394 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

decidua

stromal cell of endometrium

amniotic fluid

ascending aorta

pancreatic epithelial cell

Descending thoracic aorta

muscle layer of sigmoid colon

smooth muscle tissue

urethra

left ovary

Top expressed in

aortic valve

ascending aorta

endothelial cell of lymphatic vessel

embryo

embryo

facial motor nucleus

lens

blood

supraoptic nucleus

cumulus cell

More reference expression data

n/a

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


143903


244864


ENSG00000204381


ENSMUSG00000060594


Q6UX15


Q8C351

RefSeq (mRNA)


NM_001258390 NM_001258391 NM_178834 NM_001318799


NM_001033534

RefSeq (protein)


NP_001245319 NP_001245320 NP_001305728 NP_849156


NP_001028706

Location (UCSC)

Chr 11: 111.54 – 111.56 Mb

Chr 9: 50.97 – 50.99 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Layilin is a protein that in humans is encoded by the LAYN gene.

Medical Relevance

A study has shown that Layilin is upregulated in tumor infiltrating CD8+ Cytotoxic T cells of patients with liver cancer.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000204381 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000060594 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Layilin".
↑ Zheng C, Zheng L, Yoo JK, Guo H, Zhang Y, Guo X, Kang B, Hu R, Huang JY, Zhang Q, Liu Z, Dong M, Hu X, Ouyang W, Peng J, Zhang Z (2017). "Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing". Cell. 169 (7): 1342–1356.e16. doi:10.1016/j.cell.2017.05.035. PMID 28622514.

Further reading

Bono P, Rubin K, Higgins JM, Hynes RO (2001). "Layilin, a novel integral membrane protein, is a hyaluronan receptor". Mol. Biol. Cell. 12 (4): 891–900. doi:10.1091/mbc.12.4.891. PMC 32274. PMID 11294894.
Borowsky ML, Hynes RO (1998). "Layilin, a novel talin-binding transmembrane protein homologous with C-type lectins, is localized in membrane ruffles". J. Cell Biol. 143 (2): 429–42. doi:10.1083/jcb.143.2.429. PMC 2132847. PMID 9786953.
Forteza RM, Casalino-Matsuda SM, Falcon NS, Valencia Gattas M, Monzon ME (2012). "Hyaluronan and layilin mediate loss of airway epithelial barrier function induced by cigarette smoke by decreasing E-cadherin". J. Biol. Chem. 287 (50): 42288–98. doi:10.1074/jbc.M112.387795. PMC 3516772. PMID 23048036.
Bono P, Cordero E, Johnson K, Borowsky M, Ramesh V, Jacks T, Hynes RO (2005). "Layilin, a cell surface hyaluronan receptor, interacts with merlin and radixin". Exp. Cell Res. 308 (1): 177–87. doi:10.1016/j.yexcr.2005.04.017. PMID 15913605.

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