Leflutrozole

Leflutrozole
Clinical data
Other namesBGS-649; CGP-47645
Routes of
administration		By mouth
Identifiers
  • 4-[(4-Cyanophenyl)-fluoro-(1,2,4-triazol-1-yl)methyl]benzonitrile
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H10FN5
Molar mass303.300 g·mol−1
3D model (JSmol)
  • C1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)(N3C=NC=N3)F
  • InChI=1S/C17H10FN5/c18-17(23-12-21-11-22-23,15-5-1-13(9-19)2-6-15)16-7-3-14(10-20)4-8-16/h1-8,11-12H
  • Key:PZDLRBUQYWMNBR-UHFFFAOYSA-N

Leflutrozole (developmental code names BGS-649, CGP-47645) is an aromatase inhibitor which is under development by Mereo BioPharma and Novartis for the treatment of hypogonadism in men. It was also under investigation for the treatment of endometriosis, but development for this indication was discontinued. As of December 2017, leflutrozole is in phase II clinical trials for hypogonadism.

See also

References

  1. 1 2 3 "Leflutrozole - Mereo BioPharma". AdisInsight. Springer Nature Switzerland AG.
  2. ↑ Corona G, Rastrelli G, Sparano C, Vignozzi L, Sforza A, Maggi M (August 2024). "Pharmacological management of testosterone deficiency in men current advances and future directions". Expert Review of Clinical Pharmacology. 17 (8): 665–681. doi:10.1080/17512433.2024.2366505. PMID 38853775.