Linda Columbus

Linda Marie Columbus
Linda Columbus at the 2026 Biophysical Society Meeting
Education	Scripps Research Institute, University of California, Los Angeles Smith College
Awards	NSF CAREER Award, Cottrell Scholar Award, Virginia Outstanding Faculty Awarda
Scientific career
Workplaces	Scripps Research Institute, University of Virginia
Thesis	Investigating backbone and side chain dynamics of alpha-helices in the nanosecond regime with site-directed spin labeling (2001)
Website	Columbus Lab

Linda Columbus is an American chemist who is Professor of Chemistry and Molecular Physiology at the University of Virginia. She investigates the structure-function properties of membrane proteins.

Early life and education

Columbus was born to young parents, neither of whom were educated beyond high school, and she grew up in New Hampshire. Columbus was an undergraduate at Smith College and she earned her Ph.D. at the University of California, Los Angeles. In her doctoral research with Prof. Wayne L. Hubbell, she used spin labelling to understand the backbone and side chain dynamics of α-helices in the nanosecond regime. After earning her doctorate, Columbus joined The Scripps Research Institute as an NIH research fellow.

Research and career

Columbus joined the University of Virginia as a faculty member in 2013, and she is currently chair and professor of the Department of Chemistry and professor of Molecular Physiology and Biological Physics. She studies membrane proteins that comprise around one quarter of a proteome. These membrane proteins are involved with information transfer across lipid bilayers, and are used as drug targets. Columbus investigates the membrane proteins that mediate interactions between hosts and bacterial pathogens. To study the structures of the membrane proteins involved in cellular invasion by bacterial pathogens, Columbus uses site-directed spin labelling and nuclear magnetic resonance.

Columbus has held leadership positions within the Biophysical Society including serving as an elected member of the Biophysical Society Council, co-organizing meetings on the Molecular Biophysics of Membranes in 2022 and 2024, and serving as programming co-chair of the upcoming 2027 Biophysical Society meeting.

Awards and honors

• 2009 NSF CAREER Award
• 2010 Cottrell Scholar Award
• 2014 Virginia Outstanding Faculty Award
• 2018 Biophysical Society Council

Selected publications

• Columbus, Linda; Hubbell, Wayne (2002). "A new spin on protein dynamics". Trends in Biochemical Sciences. 27 (6): 288–295. doi:10.1016/s0968-0004(02)02095-9. PMID 12069788. Wikidata Q34691381.
• Columbus, Linda; T Kálai; J Jekö; K Hideg; W L Hubbell (2001). "Molecular motion of spin labeled side chains in alpha-helices: analysis by variation of side chain structure". Biochemistry. 40 (13): 3828–3846. doi:10.1021/bi002645h. PMID 11300763. Wikidata Q43573920. {{Cite Q}}: Missing first/last names in Wikidata for T Kálai, J Jekö, K Hideg, W L Hubbell (help)
• Lipfert, Jan; Columbus, Linda; Vincent B Chu; Scott A Lesley; Doniach, Sebastian (2007). "Size and shape of detergent micelles determined by small-angle X-ray scattering". The Journal of Physical Chemistry B. 111 (43): 12427–12438. doi:10.1021/jp073016l. PMID 17924686. Wikidata Q44871938. {{Cite Q}}: Missing first/last names in Wikidata for Vincent B Chu, Scott A Lesley (help)

References