University academics
- Mohammed-Sani Abdulai - president of Lakeside University College
- William Emmanuel Abraham - Philosopher - Author and Vice-Chancellor of the University of Ghana
- Kwasi Kwarfo Adarkwa - Academic and the past Vice Chancellor of the Kwame Nkrumah University of Science and Technology
- James Emman Kwegyir Aggrey - Intellectual, missionary and teacher
- Francis Allotey - Mathematical physicist
- Joseph Amenowode - Academic and politician
- Aba Andam - Nuclear physicist and lecturer at Kwame Nkrumah University of Science and Technology
- Kwesi Akwansah Andam - Author - civil engineer and former Vice Chancellor of Kwame Nkrumah University of Science and Technology
- Kwame Anthony Appiah - Philosopher and novelist
- George Ayittey - Economist and author
- Robert Patrick Baffour - Academic - mechanical engineer and First Vice Chancellor of the Kwame Nkrumah University of Science and Technology
- Nathaniel Boso - Academic and international marketing strategist
- George C. Clerk - Botanist
- Nicholas T. Clerk - Academic public administrator and Presbyterian Minister
- Philip Gbeho - Teacher and composer of the Ghana National Anthem
- Akua Kuenyehia - Academic and Lawyer who served as Judge of the International Criminal Court and former Dean of the Faculty of Law University of Ghana
- Fred McBagonluri - Academic - author and inventor
- Daniel Asua Wubah - Academic and President of Millersville University
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