List of SJS-inducing substances

This is a list of drugs and substances that are known or suspected to cause Stevens–Johnson syndrome.

This is a dynamic list and may never be able to satisfy particular standards for completeness. You can help by editing the page to add missing items, with references to reliable sources.
Name Other names
Allopurinol
Amoxicillin
Ampicillin
Azithromycin Zithromax
Barbiturates
Carbamazepine
Ciprofloxacin/levofloxacin/Gemifloxacin[citation needed]
Clozapine Clozaril
Cotrimoxazole Trimethoprim/sulfamethoxazole
Diclofenac
Ethosuximide[citation needed]
Glutathione
Ibuprofen
Isotretinoin Accutane
Lamotrigine Lamictal
Methazolamide Neptazane
Modafinil Provigil
Nevirapine[citation needed]
Norfloxacin
Oseltamivir[citation needed]
Oxicams Ampiroxicam, Piroxicam, Tenoxicam, Droxicam, Lornoxicam, Meloxicam, Isoxicam
Paracetamol Acetaminophen, Panadol, Tylenol
Penicillins
Phenytoin
Rivoraxaban Xarelto
Sulfonamides
Tetracycline
  1. ↑ Harr, Thomas; Smith, Lars E. (2012). "Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis". In French, Lars E. (ed.). Adverse Cutaneous Drug Eruptions, Vol 97 (Print) (Chemical Immunology and Allergy ed.). Allschwilerstrasse 10, CH-4055 Basel: S. Karger AG. pp. 149–166. ISBN 978-3-8055-9970-2. Retrieved 2026-03-27.{{cite book}}: CS1 maint: location (link)
  2. 1 2 3 4 "Stevens Johnson Syndrome". WebMD.
  3. ↑ See, e.g.: Schultz, Laura (December 28, 2015). "Potential Zithromax Side Effects Include Stevens Johnson Syndrome". Top Class Actions, LLC. Archived from the original on March 4, 2016. Retrieved December 28, 2015. Several Zithromax lawsuits have been filed against Pfizer alleging that the drug maker failed to warn the medical community and the public about serious risks associated with taking the antibiotic.
  4. ↑ Mamishi, Setareh; Fattahi, Fatemeh; Pourpak, Zahra; Aghaee, Farzaneh Mirza; Moinfar, Zeinab; Mohammadi, Mahmoud; Ashrafi, Mahmoud; Moin, Mostafa (2009-11-01). "Severe cutaneous reactions caused by barbiturates in seven Iranian children". International Journal of Dermatology. 48 (11): 1254–1261. doi:10.1111/j.1365-4632.2007.03561.x. ISSN 1365-4632. PMID 20064188. S2CID 10117062.
  5. 1 2 3 Rehmus, Wingfield E (November 2013). "Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)". Merck Manual. Merck Sharp & Dohme Corp.
  6. ↑ Wu, Ming-Kung; Chung, Weilun; Wu, Ching-Kuan; Tseng, Ping-Tao (2015-01-01). "The severe complication of Stevens-Johnson syndrome induced by long-term clozapine treatment in a male schizophrenia patient: a case report". Neuropsychiatric Disease and Treatment. 11: 1039–1041. doi:10.2147/NDT.S79327. ISSN 1176-6328. PMC 4399514. PMID 25914536.
  7. 1 2 Mockenhaupt, Maja; Viboud, Cecile; Dunant, Ariane; Naldi, Luigi; Halevy, Sima; Bavinck, Jan Nico Bouwes; Sidoroff, Alexis; Schneck, Jürgen; Roujeau, Jean-Claude; Flahault, Antoine (2008-01-01). "Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: Assessment of Medication Risks with Emphasis on Recently Marketed Drugs. The EuroSCAR-Study". Journal of Investigative Dermatology. 128 (1): 35–44. doi:10.1038/sj.jid.5701033. ISSN 0022-202X. PMID 17805350.
  8. ↑ Roujeau, J.-C., Kelly, J. P., Naldi, L., Rzany, B., Stern, R. S., Anderson, T., Auquier, A., Bastuji-Garin, S., Correia, O., Locati, F., Mockenhaupt, M., Paoletti, C., Shapiro, S., Shear, N., Schopf, E., Kaufman, D. W. (1995). "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis". N Engl J Med. 333 (1): 1600–1607. doi:10.1056/NEJM199512143332404. PMID 7477195.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  9. ↑ "Safety of off label use of Glutathione Injection" (PDF).
  10. ↑ Raksha MP, Marfatia YS (2008). "Clinical study of cutaneous drug eruptions in 200 patients". Indian J Dermatol Venereol Leprol. 74 (1): 80. doi:10.4103/0378-6323.38431. hdl:1807/48058. PMID 18193504.
  11. ↑ Medsafe Data Sheet Archived 2007-09-28 at the Wayback Machine March 8, 2005. Accessed April 26, 2007.
  12. ↑ "LAMICTAL PRESCRIBING INFORMATION" (PDF). GlaxoSmithKline. Archived from the original (PDF) on 2006-09-13. Retrieved 2009-12-17.
  13. ↑ Baluch, Amarah; Chohan, Moeed R; Warda, Katerina; Sippy, Rishab; Sandhu, Jasmine (2022). "Methazolamide Associated Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis in a Female of Caucasian Descent". Cureus. 14 (2) e21864. doi:10.7759/cureus.21864. PMC 8815805. PMID 35155038.
  14. ↑ "PROVIGIL PRESCRIBING INFORMATION" (PDF). Cephalon, Inc. Archived from the original (PDF) on 2015-05-01.
  15. ↑ "Norfloxacin" (PDF). Davis. 2017. Archived from the original (PDF) on October 27, 2017. Retrieved March 24, 2017.
  16. ↑ Khawaja A, Shahab A, Hussain SA (May 2012). "Acetaminophen-induced Steven Johnson syndrome-toxic epidermal necrolysis overlap". J Pak Med Assoc. 62 (5): 524–7. PMID 22755330.
  17. ↑ Trujillo, C.; Gago, C.; Ramos, S. (2010). "Stevens-Jonhson syndrome after acetaminophen ingestion, confirmed by challenge test in an eleven-year-old patient". Allergologia et Immunopathologia. 38 (2): 99–100. doi:10.1016/j.aller.2009.06.009. PMID 19875224.
  18. ↑ "Scientific conclusions and grounds for the variation to the terms of the marketing authorisation(s)" (PDF) (data sheet). European Medicines Agency. 6 April 2017.