M-RIP

MPRIP

Identifiers

MPRIP, M-RIP, MRIP, RHOIP3, RIP3, p116Rip, myosin phosphatase Rho interacting protein

External IDs

OMIM: 612935; MGI: 1349438; GeneCards: MPRIP

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17p11.2	Start	17,042,457 bp
Band	17p11.2	End	17,217,679 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11\|11 B1.3	Start	59,552,131 bp
Band	11\|11 B1.3	End	59,671,686 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

popliteal artery

tibial arteries

sural nerve

right coronary artery

amniotic fluid

olfactory bulb

saphenous vein

body of uterus

ganglionic eminence

buccal mucosa cell

Top expressed in

spermatid

CA3 field

lactiferous gland

ankle joint

entorhinal cortex

choroid plexus of fourth ventricle

perirhinal cortex

left lung

seminiferous tubule

right lung

More reference expression data


More reference expression data

Gene ontology
Molecular function	actin binding protein binding cadherin binding
Cellular component	cytoskeleton focal adhesion actin cytoskeleton cytoplasm cytosol
Biological process	cell-cell adhesion
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23164


26936


ENSG00000133030


ENSMUSG00000005417


Q6WCQ1


P97434

RefSeq (mRNA)


NM_015134 NM_201274 NM_001364716


NM_012027 NM_201245 NM_001368931

RefSeq (protein)


NP_055949 NP_958431 NP_001351645


NP_036157 NP_957697 NP_001355860

Location (UCSC)

Chr 17: 17.04 – 17.22 Mb

Chr 11: 59.55 – 59.67 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Myosin phosphatase Rho-interacting protein is an enzyme that in humans is encoded by the MPRIP gene.

Interactions

M-RIP has been shown to interact with RHOA.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133030 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005417 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
↑ "Entrez Gene: M-RIP myosin phosphatase-Rho interacting protein".
↑ Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (Jun 1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7): 1603–13. doi:10.1083/jcb.137.7.1603. PMC 2137826. PMID 9199174.

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Gebbink MF, Kranenburg O, Poland M, van Horck FP, Houssa B, Moolenaar WH (1997). "Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology". J. Cell Biol. 137 (7): 1603–13. doi:10.1083/jcb.137.7.1603. PMC 2137826. PMID 9199174.
Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–93. doi:10.1074/jbc.M305622200. PMID 14506264.
Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Mulder J, Ariaens A, van den Boomen D, Moolenaar WH (2005). "p116Rip targets myosin phosphatase to the actin cytoskeleton and is essential for RhoA/ROCK-regulated neuritogenesis". Mol. Biol. Cell. 15 (12): 5516–27. doi:10.1091/mbc.E04-04-0275. PMC 532030. PMID 15469989.
Koga Y, Ikebe M (2005). "p116Rip decreases myosin II phosphorylation by activating myosin light chain phosphatase and by inactivating RhoA". J. Biol. Chem. 280 (6): 4983–91. doi:10.1074/jbc.M410909200. PMID 15545284.
Benzinger A, Muster N, Koch HB, Yates JR, Hermeking H (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Surks HK, Riddick N, Ohtani K (2006). "M-RIP targets myosin phosphatase to stress fibers to regulate myosin light chain phosphorylation in vascular smooth muscle cells". J. Biol. Chem. 280 (52): 42543–51. doi:10.1074/jbc.M506863200. PMID 16257966.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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