MAGI3

MAGI3

Identifiers

MAGI3, MAGI-3, dJ730K3.2, membrane associated guanylate kinase, WW and PDZ domain containing 3

External IDs

OMIM: 615943; MGI: 1923484; GeneCards: MAGI3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3SOE

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1p13.2	Start	113,390,515 bp
Band	1p13.2	End	113,685,923 bp

Gene location (Mouse)

Chr.	Chromosome 3 (mouse)

Band	3 F2.2\|3 45.52 cM	Start	103,920,575 bp
Band	3 F2.2\|3 45.52 cM	End	104,127,690 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

lower lobe of lung

nasal epithelium

mucosa of ileum

jejunal mucosa

mucosa of colon

palpebral conjunctiva

mucosa of sigmoid colon

corpus epididymis

pars compacta

mucosa of pharynx

Top expressed in

atrioventricular valve

globus pallidus

habenula

superior colliculus

dorsal tegmental nucleus

left lung lobe

medial vestibular nucleus

ventral tegmental area

ciliary body

piriform cortex

More reference expression data

n/a

Gene ontology
Molecular function	molecular adaptor activity nucleotide binding guanylate kinase activity protein binding ATP binding
Cellular component	plasma membrane membrane nucleus cell-cell junction bicellular tight junction cell junction cytoplasm
Biological process	regulation of JNK cascade intracellular signal transduction viral process signal transduction apoptotic process GDP metabolic process GMP metabolic process
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


260425


99470


ENSG00000081026


ENSMUSG00000052539


Q5TCQ9


Q9EQJ9

RefSeq (mRNA)


NM_001142782 NM_020965 NM_152900


NM_001159354 NM_133853

RefSeq (protein)


NP_001136254 NP_690864 NP_690864.2


NP_001152826 NP_598614

Location (UCSC)

Chr 1: 113.39 – 113.69 Mb

Chr 3: 103.92 – 104.13 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 is an enzyme that in humans is encoded by the MAGI3 gene.

Interactions

MAGI3 has been shown to interact with PTPRB and PTEN.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000081026 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052539 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Dec 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
1 2 Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, Lasky LA (Aug 2000). "Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase". J Biol Chem. 275 (28): 21477–85. doi:10.1074/jbc.M909741199. PMID 10748157.
↑ "Entrez Gene: MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3".
↑ Adamsky, Konstantin; Arnold Katya; Sabanay Helena; Peles Elior (Apr 2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell Sci. 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. ISSN 0021-9533. PMID 12615970.

Further reading

Zhang H, Wang D, Sun H, et al. (2007). "MAGI-3 regulates LPA-induced activation of Erk and RhoA". Cell. Signal. 19 (2): 261–8. doi:10.1016/j.cellsig.2006.06.008. PMC 1995035. PMID 16904289.
He J, Bellini M, Inuzuka H, et al. (2006). "Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins". J. Biol. Chem. 281 (5): 2820–7. doi:10.1074/jbc.M509503200. PMID 16316992.
Franklin JL, Yoshiura K, Dempsey PJ, et al. (2005). "Identification of MAGI-3 as a transforming growth factor-alpha tail binding protein". Exp. Cell Res. 303 (2): 457–70. doi:10.1016/j.yexcr.2004.10.007. PMID 15652357.
Yao R, Natsume Y, Noda T (2005). "MAGI-3 is involved in the regulation of the JNK signaling pathway as a scaffold protein for frizzled and Ltap". Oncogene. 23 (36): 6023–30. doi:10.1038/sj.onc.1207817. PMID 15195140.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Adamsky K, Arnold K, Sabanay H, Peles E (2003). "Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins". J. Cell Sci. 116 (Pt 7): 1279–89. doi:10.1242/jcs.00302. PMID 12615970.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Thomas M, Laura R, Hepner K, et al. (2002). "Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation". Oncogene. 21 (33): 5088–96. doi:10.1038/sj.onc.1205668. PMID 12140759.
Laura RP, Ross S, Koeppen H, Lasky LA (2002). "MAGI-1: a widely expressed, alternatively spliced tight junction protein". Exp. Cell Res. 275 (2): 155–70. doi:10.1006/excr.2002.5475. PMID 11969287.

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