MAN1B1

MAN1B1

Identifiers

MAN1B1, ERMAN1, MANA-ER, MRT15, ERManI, mannosidase alpha class 1B member 1

External IDs

OMIM: 604346; MGI: 2684954; GeneCards: MAN1B1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1FMI, 1FO2, 1FO3, 1X9D

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
3.2.1.113	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9q34.3	Start	137,086,857 bp
Band	9q34.3	End	137,109,189 bp

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)

Band	2\|2 A3	Start	25,222,350 bp
Band	2\|2 A3	End	25,242,224 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

right uterine tube

skin of leg

anterior pituitary

apex of heart

skin of abdomen

right hemisphere of cerebellum

minor salivary glands

olfactory zone of nasal mucosa

right lobe of thyroid gland

Top expressed in

spermatocyte

Ileal epithelium

spermatid

neural layer of retina

yolk sac

corneal stroma

granulocyte

ventricular zone

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

More reference expression data


More reference expression data

Gene ontology
Molecular function	metal ion binding calcium ion binding hydrolase activity, acting on glycosyl bonds hydrolase activity mannosyl-oligosaccharide 1,2-alpha-mannosidase activity catalytic activity
Cellular component	extracellular vesicle integral component of membrane Golgi apparatus membrane endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum quality control compartment Golgi membrane
Biological process	oligosaccharide metabolic process metabolism N-glycan processing mannose trimming involved in glycoprotein ERAD pathway protein alpha-1,2-demannosylation protein glycosylation ubiquitin-dependent ERAD pathway trimming of terminal mannose on B branch trimming of terminal mannose on C branch trimming of first mannose on A branch trimming of second mannose on A branch endoplasmic reticulum mannose trimming
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


11253


227619


ENSG00000177239


ENSMUSG00000036646


Q9UKM7


A2AJ15

RefSeq (mRNA)


NM_016219


NM_001029983

RefSeq (protein)


NP_057303


NP_001025154

Location (UCSC)

Chr 9: 137.09 – 137.11 Mb

Chr 2: 25.22 – 25.24 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase is an enzyme that in humans is encoded by the MAN1B1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177239 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036646 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Gonzalez DS, Karaveg K, Vandersall-Nairn AS, Lal A, Moremen KW (Aug 1999). "Identification, expression, and characterization of a cDNA encoding human endoplasmic reticulum mannosidase I, the enzyme that catalyzes the first mannose trimming step in mammalian Asn-linked oligosaccharide biosynthesis". J Biol Chem. 274 (30): 21375–86. doi:10.1074/jbc.274.30.21375. PMID 10409699.
↑ Tremblay LO, Herscovics A (Nov 1999). "Cloning and expression of a specific human alpha 1,2-mannosidase that trims Man9GlcNAc2 to Man8GlcNAc2 isomer B during N-glycan biosynthesis". Glycobiology. 9 (10): 1073–8. doi:10.1093/glycob/9.10.1073. PMID 10521544.
↑ "Entrez Gene: MAN1B1 mannosidase, alpha, class 1B, member 1".

Further reading

Land A, Braakman I (2001). "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie. 83 (8): 783–90. doi:10.1016/S0300-9084(01)01314-1. hdl:1874/5091. PMID 11530211. S2CID 13576808.
Dedera DA, Gu RL, Ratner L (1992). "Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function". Virology. 187 (1): 377–82. doi:10.1016/0042-6822(92)90331-I. PMID 1736542.
Kalyanaraman VS, Rodriguez V, Veronese F, et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1". AIDS Res. Hum. Retroviruses. 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
Shimizu H, Tsuchie H, Honma H, et al. (1991). "Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins". Jpn. J. Med. Sci. Biol. 43 (3): 75–87. doi:10.7883/yoken1952.43.75. PMID 2283726.
Leonard CK, Spellman MW, Riddle L, et al. (1990). "Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells". J. Biol. Chem. 265 (18): 10373–82. doi:10.1016/S0021-9258(18)86956-3. PMID 2355006.
Stein BS, Engleman EG (1990). "Intracellular processing of the gp160 HIV-1 envelope precursor. Endoproteolytic cleavage occurs in a cis or medial compartment of the Golgi complex". J. Biol. Chem. 265 (5): 2640–9. doi:10.1016/S0021-9258(19)39849-7. PMID 2406237.
Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. Bibcode:1989PNAS...86.3384P. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport". J. Virol. 63 (6): 2452–6. doi:10.1128/jvi.63.6.2452-2456.1989. PMC 250699. PMID 2542563.
Kozarsky K, Penman M, Basiripour L, et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis". AIDS Res. Hum. Retroviruses. 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
Blough HA, Pauwels R, De Clercq E, et al. (1987). "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
Montefiori DC, Robinson WE, Mitchell WM (1988). "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. Bibcode:1988PNAS...85.9248M. doi:10.1073/pnas.85.23.9248. PMC 282716. PMID 3264072.
Fenouillet E, Jones I, Powell B, et al. (1993). "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. doi:10.1128/jvi.67.1.150-160.1993. PMC 237347. PMID 8093218.
Yeh JC, Seals JR, Murphy CI, et al. (1993). "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry. 32 (41): 11087–99. doi:10.1021/bi00092a019. PMID 8218172.
Bolmstedt A, Sjölander S, Hansen JE, et al. (1996). "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. doi:10.1097/00042560-199607000-00001. PMID 8673525.
Hu H, Shioda T, Moriya C, et al. (1996). "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. doi:10.1128/jvi.70.11.7462-7470.1996. PMC 190813. PMID 8892864.
Papandreou MJ, Fenouillet E (1997). "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. S2CID 17660.
Tremblay LO, Campbell Dyke N, Herscovics A (1998). "Molecular cloning, chromosomal mapping and tissue-specific expression of a novel human alpha1,2-mannosidase gene involved in N-glycan maturation". Glycobiology. 8 (6): 585–95. doi:10.1093/glycob/8.6.585. PMID 9592125.

v t e PDB gallery
1fmi: CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE 1fo2: CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH 1-DEOXYMANNOJIRIMYCIN 1fo3: CRYSTAL STRUCTURE OF HUMAN CLASS I ALPHA1,2-MANNOSIDASE IN COMPLEX WITH KIFUNENSINE 1x9d: Crystal Structure Of Human Class I alpha-1,2-Mannosidase In Complex With Thio-Disaccharide Substrate Analogue

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