MAP3K15

MAP3K15
Identifiers
Aliases	MAP3K15, ASK3, bA723P2.3, mitogen-activated protein kinase kinase kinase 15
External IDs	OMIM: 300820; MGI: 2448588; GeneCards: MAP3K15
Enzyme activity
Gene location (Human)
Chr.	X chromosome (human)
End	19,515,508 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	158,906,347 bp
RNA expression pattern
	Top expressed in
	right adrenal cortex; ; left adrenal cortex; ; islet of Langerhans; ; testicle; ; spleen; ; gonad; ; human kidney; ; pituitary gland; ; anterior pituitary; ; ganglionic eminence;
	Top expressed in
	granulocyte; ; proximal tubule; ; islet of Langerhans; ; right kidney; ; human kidney; ; secondary oocyte; ; primary oocyte; ; epiblast; ; zygote; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; MAP kinase kinase kinase activity; ATP binding; metal ion binding; kinase activity;
Cellular component	intracellular anatomical structure;
Biological process	protein phosphorylation; phosphorylation; MAPK cascade;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	389840
	270672
	ENSG00000180815
	ENSMUSG00000031303
	Q6ZN16
	A2AQW0
	NM_001001671
	NM_001163085
	NP_001001671
	NP_001156557
	Wikidata
View/Edit Human	View/Edit Mouse

Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene.

Function

The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates a specific MAPK. This MAP3K protein plays an essential role in apoptotic cell death triggered by cellular stresses.

1 2 3 GRCh38: Ensembl release 89: ENSG00000180815 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031303 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Mitogen-activated protein kinase kinase kinase 15". Retrieved 2017-05-25.