MDA-MB-468

MDA-MB-468 is a cell line that was isolated from a 51-year-old female human in 1977, and is commonly used in breast cancer research. MDA-MB-468 cells were extracted from a pleural effusion of mammary gland and breast tissues, and have proven useful for the study of metastasis, migration, and breast cancer proliferation.

The cell line was isolated in 1977 by Relda Cailleau, et al., from a pleural effusion of a 51-year-old Black female patient with metastatic adenocarcinoma of the breast. Although the tissue donor was heterozygous for G6PD alleles, the cell line consistently showed only the G6PD A phenotype. MDA-MB-468 cells have a modal chromosome number of 64, though the actual number can vary from 60 to 67 in different cells.[citation needed]

MDA-MB-468 has been used to test chemical breast cancer treatments.

See also

References

  1. ↑ Quinsgaard, Ellen Marie Botne; Korsnes, Mónica Suárez; Korsnes, Reinert; Moestue, Siver Andreas (2024-04-01). "Single-cell tracking as a tool for studying EMT-phenotypes". Experimental Cell Research. 437 (1): 113993. doi:10.1016/j.yexcr.2024.113993. hdl:11250/3148463. ISSN 0014-4827.{{cite journal}}: CS1 maint: article number as page number (link)
  2. ↑ Korsnes, Mónica Suárez; Quinsgaard, Ellen Marie Botne; Moestue, Siver Andreas; Korsnes, Reinert (2026-09-14). "Lineage-resolved lifetime modelling reveals potential quiescence and synchronization among MDA-MB-468 breast cancer cells". Frontiers in Cell and Developmental Biology. 14. Frontiers. doi:10.3389/fcell.2026.1911886. ISSN 2296-634X. PMC 13624361. PMID 42818886.
  3. ↑ Wang, WL; Porter, W; et al. (May 1997). "Mechanism of inhibition of MDA-MB-468 breast cancer cell growth by 2,3,7,8-tetrachlorodibenzo-p-dioxin". Carcinogenesis. 18 (5): 925–933. doi:10.1093/carcin/18.5.925. PMID 9163677.