MCF2L

MCF2L

Identifiers

MCF2L, ARHGEF14, DBS, OST, MCF.2 cell line derived transforming sequence like

External IDs

OMIM: 609499; MGI: 103263; GeneCards: MCF2L

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1KZ7, 1KZG, 1LB1, 1RJ2

Gene location (Human)

Chr.	Chromosome 13 (human)

Band	13q34	Start	112,894,378 bp
Band	13q34	End	113,099,742 bp

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)

Band	8\|8 A1.1	Start	12,873,806 bp
Band	8\|8 A1.1	End	13,020,905 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

right frontal lobe

paraflocculus of cerebellum

pituitary gland

apex of heart

anterior pituitary

C1 segment

Brodmann area 9

prefrontal cortex

primary visual cortex

Top expressed in

olfactory epithelium

neural layer of retina

cerebellar cortex

primary visual cortex

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

pituitary gland

lobe of cerebellum

cerebellar vermis

islet of Langerhans

More reference expression data


More reference expression data

Gene ontology
Molecular function	phosphatidylinositol binding lipid binding guanyl-nucleotide exchange factor activity
Cellular component	cytoplasm extrinsic component of cytoplasmic side of plasma membrane cytosol plasma membrane membrane endomembrane system extracellular space
Biological process	positive regulation of Rho protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction regulation of small GTPase mediated signal transduction positive regulation of apoptotic process G protein-coupled receptor signaling pathway regulation of molecular function
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23263


17207


ENSG00000126217


ENSMUSG00000031442


O15068


Q64096

RefSeq (mRNA)

NM_001112732 NM_024979 NM_001320815 NM_001320816 NM_001320817
NM_001366644 NM_001366645 NM_001366646


NM_001159485 NM_001159486 NM_178076

RefSeq (protein)

NP_001106203 NP_001307744 NP_001307745 NP_001307746 NP_079255
NP_001353573 NP_001353574 NP_001353575


n/a

Location (UCSC)

Chr 13: 112.89 – 113.1 Mb

Chr 8: 12.87 – 13.02 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Guanine nucleotide exchange factor DBS is a protein that in humans is encoded by the MCF2L gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000126217 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031442 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Apr 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
↑ "Entrez Gene: MCF2L MCF.2 cell line derived transforming sequence-like".

Further reading

Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T (Oct 1994). "A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links Rho and Rac signaling pathways". The EMBO Journal. 13 (20): 4776–86. doi:10.1002/j.1460-2075.1994.tb06803.x. PMC 395416. PMID 7957046.
Rossman KL, Worthylake DK, Snyder JT, Siderovski DP, Campbell SL, Sondek J (Mar 2002). "A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange". The EMBO Journal. 21 (6): 1315–26. doi:10.1093/emboj/21.6.1315. PMC 125919. PMID 11889037.
Snyder JT, Worthylake DK, Rossman KL, Betts L, Pruitt WM, Siderovski DP, Der CJ, Sondek J (Jun 2002). "Structural basis for the selective activation of Rho GTPases by Dbl exchange factors". Nature Structural Biology. 9 (6): 468–75. doi:10.1038/nsb796. PMID 12006984. S2CID 13161854.
Yamauchi J, Hirasawa A, Miyamoto Y, Kokubu H, Nishii H, Okamoto M, Sugawara Y, Tsujimoto G, Itoh H (Aug 2002). "Role of Dbl's big sister in the anti-mitogenic pathway from alpha1B-adrenergic receptor to c-Jun N-terminal kinase". Biochemical and Biophysical Research Communications. 296 (1): 85–92. doi:10.1016/S0006-291X(02)00839-2. PMID 12147231.
Wennerberg K, Ellerbroek SM, Liu RY, Karnoub AE, Burridge K, Der CJ (Dec 2002). "RhoG signals in parallel with Rac1 and Cdc42". The Journal of Biological Chemistry. 277 (49): 47810–7. doi:10.1074/jbc.M203816200. PMID 12376551.
Cheng L, Mahon GM, Kostenko EV, Whitehead IP (Mar 2004). "Pleckstrin homology domain-mediated activation of the rho-specific guanine nucleotide exchange factor Dbs by Rac1". The Journal of Biological Chemistry. 279 (13): 12786–93. doi:10.1074/jbc.M313099200. PMID 14701795.
Ueda S, Kataoka T, Satoh T (Aug 2004). "Role of the Sec14-like domain of Dbl family exchange factors in the regulation of Rho family GTPases in different subcellular sites" (PDF). Cellular Signalling. 16 (8): 899–906. doi:10.1016/j.cellsig.2004.01.007. hdl:20.500.14094/D1002967. PMID 15157669. Archived from the original (PDF) on 2020-07-21. Retrieved 2020-07-21.
Kostenko EV, Mahon GM, Cheng L, Whitehead IP (Jan 2005). "The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs". The Journal of Biological Chemistry. 280 (4): 2807–17. doi:10.1074/jbc.M411139200. PMID 15531584.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Ieguchi K, Ueda S, Kataoka T, Satoh T (Aug 2007). "Role of the guanine nucleotide exchange factor Ost in negative regulation of receptor endocytosis by the small GTPase Rac1". The Journal of Biological Chemistry. 282 (32): 23296–305. doi:10.1074/jbc.M700950200. hdl:20.500.14094/D1004143. PMID 17562712.

v t e PDB gallery
1kz7: Crystal Structure of the DH/PH Fragment of Murine Dbs in Complex with the Placental Isoform of Human Cdc42 1kzg: DbsCdc42(Y889F) 1lb1: Crystal Structure of the Dbl and Pleckstrin homology domains of Dbs in complex with RhoA 1rj2: Crystal structure of the DH/PH fragment of Dbs without bound GTPase

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