MCM9

MCM9
Identifiers
Aliases	MCM9, C6orf61, MCMDC1, dJ329L24.1, dJ329L24.3, ODG4, minichromosome maintenance 9 homologous recombination repair factor
External IDs	OMIM: 610098; MGI: 1918817; GeneCards: MCM9
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	118,935,162 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	53,506,535 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; bronchial epithelial cell; ; testicle; ; monocyte; ; gonad; ; Achilles tendon; ; palpebral conjunctiva; ; sural nerve; ; ventricular zone; ; right uterine tube;
	Top expressed in
	zygote; ; secondary oocyte; ; cumulus cell; ; ureter; ; genital tubercle; ; primary oocyte; ; tail of embryo; ; ventricular zone; ; embryo; ; thymus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; nucleotide binding; hydrolase activity; ATP binding; helicase activity; DNA helicase activity; chromatin binding; protein binding; enzyme binding; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein-containing complex binding; DNA replication origin binding; single-stranded DNA binding;
Cellular component	nucleus; MCM8-MCM9 complex; chromosome; MCM complex;
Biological process	gamete generation; female gamete generation; DNA repair; cellular response to DNA damage stimulus; double-strand break repair via homologous recombination; DNA replication initiation; DNA replication; DNA duplex unwinding; recombinational interstrand cross-link repair; mismatch repair involved in maintenance of fidelity involved in DNA-dependent DNA replication; protein localization to chromatin;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	254394
	71567
	ENSG00000111877
	ENSMUSG00000058298
	Q9NXL9
	Q2KHI9
	NM_153255; NM_017696
	NM_027830
NP_060166; NP_694987; NP_001365285; NP_001365286; NP_001365287;
	NP_001365288; NP_001365289; NP_001365290; NP_001365291; NP_001365292; NP_001365293; NP_001365294; NP_001365295; NP_001365296; NP_001365297; NP_001365298; NP_001365299; NP_001365300; NP_001365301
	NP_082106
	Wikidata
View/Edit Human	View/Edit Mouse

DNA helicase MCM9 is an enzyme that in humans is encoded by the MCM9 gene. Copies of MCM8 and this protein combine together to form a heterohexamer (6-component) complex, which functions as a helicase and participates in DNA repair.

Medical Significance

Pathogenic mutations in MCM9 are associated with incomplete development of female secondary sexual characteristics, amenorrhea (not having periods), and ovaries which were either small or not visible on ultrasounds. This condition appears to be inherited in an autosomal recessive way, and has been denoted ovarian dysgenesis 4 (ODG4).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000111877 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058298 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "DNA helicase MCM9". uniprot.org. UniProt consortium. Retrieved 2026-10-13.
1 2 Helderman NC, Terlouw D, Bonjoch L, Golubicki M, Antelo M, Morreau H, van Wezel T, Castellvi-Bel S, Goldberg Y, Nielsen M (2023-06-16). "Molecular functions of MCM8 and MCM9 and their associated pathologies". iScience. 26 (6) 106737. Bibcode:2023iSci...26j6737H. doi:10.1016/j.isci.2023.106737. PMC 10291252. PMID 37378315.
1 2 O'Neill MJ, Muriello M (2025-06-09). "OVARIAN DYSGENESIS 4; ODG4". Online Mendelian Inheritance in Man. Johns Hopkins university. Retrieved 2026-10-13.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000111877 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058298 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 "DNA helicase MCM9". uniprot.org. UniProt consortium. Retrieved 2026-10-13.

[Helderman2023-6] 1 2 Helderman NC, Terlouw D, Bonjoch L, Golubicki M, Antelo M, Morreau H, van Wezel T, Castellvi-Bel S, Goldberg Y, Nielsen M (2023-06-16). "Molecular functions of MCM8 and MCM9 and their associated pathologies". iScience. 26 (6) 106737. Bibcode:2023iSci...26j6737H. doi:10.1016/j.isci.2023.106737. PMC 10291252. PMID 37378315.

[omim-7] 1 2 O'Neill MJ, Muriello M (2025-06-09). "OVARIAN DYSGENESIS 4; ODG4". Online Mendelian Inheritance in Man. Johns Hopkins university. Retrieved 2026-10-13.