MDGA2

MDGA2
Identifiers
Aliases	MDGA2, MAMDC1, c14_5286, MAM domain containing glycosylphosphatidylinositol anchor 2
External IDs	OMIM: 611128; MGI: 2444706; GeneCards: MDGA2
Gene location (Human)
Chr.	Chromosome 14 (human)
End	47,675,605 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	67,269,323 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; ventricular zone; ; prefrontal cortex; ; corpus callosum; ; C1 segment; ; ganglionic eminence; ; Brodmann area 9; ; stromal cell of endometrium; ; primary visual cortex;
	Top expressed in
	lateral septal nucleus; ; ventromedial nucleus; ; supraoptic nucleus; ; inferior colliculi; ; paraventricular nucleus of hypothalamus; ; lateral hypothalamus; ; medial dorsal nucleus; ; anterior amygdaloid area; ; medial geniculate nucleus; ; globus pallidus;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	161357
	320772
	ENSG00000139915
	ENSMUSG00000034912
	Q7Z553
	P60755
	NM_001113498; NM_182830
	NM_001193266; NM_207010
	NP_001106970; NP_878250
	NP_001180195; NP_996893
	Wikidata
View/Edit Human	View/Edit Mouse

MDGA2 (MAM domain containing glycosylphosphatidylinositol anchor 2) is a human gene. It has previously been called MAMDC1. MDGA2 is located on chromosome 14.

The gene has a homologue in rat and mouse, Mdga2, and investigations in rats have found that the gene is expressed in the central and peripheral nervous system in a subpopulation of neurons, e.g., in the basilar pons and cerebral cortex.

There are several variants in the human gene, and a genome-wide association study has pointed to that single-nucleotide polymorphisms in MDGA2 is associated with neuroticism. However, a more recent study has failed to replicate that finding.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000139915 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034912 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.
↑ RGD. "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.
↑ Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neurosciences. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943. S2CID 25186151.
↑ "SNP linked to Gene MDGA2". NCBI.
↑ van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, et al. (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.
↑ Hettema JM, van den Oord EJ, An SS, Kendler KS, Chen X (August 2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892. PMID 19440164.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000139915 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034912 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "MDGA2 Gene — GeneCards". Weizmann Institute of Science. 2008-09-08.

[6] RGD. "Rat Genome Database: Mdga2 ( Rattus norvegicus )". Medical College of Wisconsin. Retrieved 2008-11-14.

[7] Litwack ED, Babey R, Buser R, Gesemann M, O'Leary DD (February 2004). "Identification and characterization of two novel brain-derived immunoglobulin superfamily members with a unique structural organization". Molecular and Cellular Neurosciences. 25 (2): 263–264. doi:10.1016/j.mcn.2003.10.016. PMID 15019943. S2CID 25186151.

[8] "SNP linked to Gene MDGA2". NCBI.

[9] van den Oord EJ, Kuo PH, Hartmann AM, Webb BT, Möller HJ, Hettema JM, et al. (September 2008). "18762592". Archives of General Psychiatry. 65 (9): 1062–1071. doi:10.1001/archpsyc.65.9.1062. PMID 18762592.

[10] Hettema JM, van den Oord EJ, An SS, Kendler KS, Chen X (August 2009). "Follow-up association study of novel neuroticism gene MAMDC1". Psychiatric Genetics. 19 (4): 213–214. doi:10.1097/ypg.0b013e32832cec22. PMC 2844892. PMID 19440164.