MED20

MED20
Identifiers
Aliases	MED20, PRO0213, TRFP, mediator complex subunit 20, SRB2
External IDs	OMIM: 612915; MGI: 1929648; GeneCards: MED20
Gene location (Human)
Chr.	Chromosome 6 (human)
End	41,921,139 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	47,624,418 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; gingival epithelium; ; ganglionic eminence; ; hair follicle; ; gastrocnemius muscle; ; testicle; ; right adrenal cortex;
	Top expressed in
	Paneth cell; ; medullary collecting duct; ; endocardial cushion; ; condyle; ; conjunctival fornix; ; external carotid artery; ; primary oocyte; ; internal carotid artery; ; renal corpuscle; ; secondary oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transcription coactivator activity; transcription coregulator activity; protein binding; ubiquitin protein ligase activity;
Cellular component	mediator complex; nucleus; nucleoplasm; ubiquitin ligase complex;
Biological process	transcription initiation from RNA polymerase II promoter; regulation of transcription, DNA-templated; transcription by RNA polymerase II; protein ubiquitination; transcription, DNA-templated; regulation of transcription by RNA polymerase II; skeletal muscle cell differentiation; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9477
	56771
	ENSG00000124641
	ENSMUSG00000092558
	Q9H944
	Q9R0X0
	NM_001305455; NM_001305456; NM_001305457; NM_004275
	NM_020048
	NP_001292384; NP_001292385; NP_001292386; NP_004266
	NP_064432; NP_001351855; NP_001351856
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 20 (Med20) is a protein that in humans is encoded by the MED20 gene. Mutations in the MED20 are associated with basal ganglia degeneration and brain atrophy in infants.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124641 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000092558 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, et al. (July 2021). "The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity". Cell Reports. 36 (1) 109314. doi:10.1016/j.celrep.2021.109314. PMID 34233190.
↑ Vodopiutz J, Schmook MT, Konstantopoulou V, Plecko B, Greber-Platzer S, Creus M, et al. (January 2015). "MED20 mutation associated with infantile basal ganglia degeneration and brain atrophy". European Journal of Pediatrics. 174 (1): 113–118. doi:10.1007/s00431-014-2463-7. PMID 25446406.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124641 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000092558 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Tang WS, Weng L, Wang X, Liu CQ, Hu GS, Yin ST, et al. (July 2021). "The Mediator subunit MED20 organizes the early adipogenic complex to promote development of adipose tissues and diet-induced obesity". Cell Reports. 36 (1) 109314. doi:10.1016/j.celrep.2021.109314. PMID 34233190.

[6] Vodopiutz J, Schmook MT, Konstantopoulou V, Plecko B, Greber-Platzer S, Creus M, et al. (January 2015). "MED20 mutation associated with infantile basal ganglia degeneration and brain atrophy". European Journal of Pediatrics. 174 (1): 113–118. doi:10.1007/s00431-014-2463-7. PMID 25446406.

MED20

See also

References