MED29

MED29
Identifiers
Aliases	MED29, IXL, MED2, mediator complex subunit 29
External IDs	OMIM: 612914; MGI: 1914474; GeneCards: MED29
Gene location (Human)
Chr.	Chromosome 19 (human)
End	39,400,641 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	28,092,133 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; amygdala; ; cingulate gyrus; ; anterior cingulate cortex; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; hypothalamus; ; C1 segment; ; muscle of thigh;
	Top expressed in
	interventricular septum; ; lumbar spinal ganglion; ; morula; ; yolk sac; ; seminiferous tubule; ; embryo; ; embryo; ; right kidney; ; otic placode; ; epiblast;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	mediator complex; nucleus; nucleoplasm;
Biological process	regulation of transcription, DNA-templated; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55588
	67224
	ENSG00000063322
	ENSMUSG00000003444
	Q9NX70
	Q9DB91
	NM_017592; NM_001317770
	NM_026042
	NP_001304699; NP_060062
	NP_080318
	Wikidata
View/Edit Human	View/Edit Mouse

Mediator of RNA polymerase II transcription subunit 29 (Med29) is a transcription suppressor that in humans is encoded by the MED29 gene. It represents subunit MED29 of the Mediator complex.

Med29, along with Med11 and Med28 in mammals, is part of the core head-region of the Mediator complex. Med29 is the apparent orthologue of the Drosophila melanogaster Intersex protein (IXL), which interacts directly with, and functions as a transcriptional coactivator for, the DNA-binding transcription factor Doublesex, so it is likely that mammalian Med29 serves as a target for one or more DNA-binding transcriptional activators.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000063322 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003444 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wang Y, Li Y, Zeng W, Zhu C, Xiao J, Yuan W, et al. (2004). "IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor". Biochem Biophys Res Commun. 325 (4): 1330–8. doi:10.1016/j.bbrc.2004.10.159. PMID 15555573.
↑ Conaway RC, Sato S, Tomomori-Sato C, Yao T, Conaway JW (May 2005). "The mammalian Mediator complex and its role in transcriptional regulation". Trends Biochem. Sci. 30 (5): 250–5. doi:10.1016/j.tibs.2005.03.002. PMID 15896743.

This article incorporates text from the public domain Pfam and InterPro: IPR021018