MED7 Protein-coding gene in the species Homo sapiens
Mediator of RNA polymerase II transcription subunit 7 is an enzyme that in humans is encoded by the MED7 gene .
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Further reading
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry" . Mol. Syst. Biol . 3 (1): 89. doi :10.1038/msb4100134 . PMC 1847948 PMID 17353931 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Sato S, Tomomori-Sato C, Parmely TJ, et al. (2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology" . Mol. Cell . 14 (5): 685– 91. doi :10.1016/j.molcel.2004.05.006 PMID 15175163 . Tomomori-Sato C, Sato S, Parmely TJ, et al. (2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2" . J. Biol. Chem . 279 (7): 5846– 51. doi :10.1074/jbc.M312523200 PMID 14638676 . Sato S, Tomomori-Sato C, Banks CA, et al. (2004). "A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex" . J. Biol. Chem . 278 (50): 49671– 4. doi :10.1074/jbc.C300444200 PMID 14576168 . Sato S, Tomomori-Sato C, Banks CA, et al. (2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3" . J. Biol. Chem . 278 (17): 15123– 7. doi :10.1074/jbc.C300054200 PMID 12584197 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Ryu S, Tjian R (1999). "Purification of transcription cofactor complex CRSP" . Proc. Natl. Acad. Sci. U.S.A . 96 (13): 7137– 42. Bibcode :1999PNAS...96.7137R . doi :10.1073/pnas.96.13.7137 PMC 22029 PMID 10377381 . Näär AM, Beaurang PA, Zhou S, et al. (1999). "Composite co-activator ARC mediates chromatin-directed transcriptional activation". Nature . 398 (6730): 828– 32. Bibcode :1999Natur.398..828N . doi :10.1038/19789 . PMID 10235267 . S2CID 23646963 . Jiang YW, Veschambre P, Erdjument-Bromage H, et al. (1998). "Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways" . Proc. Natl. Acad. Sci. U.S.A . 95 (15): 8538– 43. Bibcode :1998PNAS...95.8538J . doi :10.1073/pnas.95.15.8538 PMC 21111 PMID 9671713 . Myers LC, Gustafsson CM, Bushnell DA, et al. (1998). "The Med proteins of yeast and their function through the RNA polymerase II carboxy-terminal domain" . Genes Dev . 12 (1): 45– 54. doi :10.1101/gad.12.1.45 . PMC 316402 PMID 9420330 .
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