Mesoderm-specific transcript homolog protein

MEST
Identifiers
Aliases	MEST, PEG1, mesoderm specific transcript
External IDs	OMIM: 601029; MGI: 96968; GeneCards: MEST
Gene location (Human)
Chr.	Chromosome 7 (human)
End	130,506,465 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	30,748,465 bp
RNA expression pattern
	Top expressed in
	cartilage tissue; ; placenta; ; secondary oocyte; ; pericardium; ; parietal pleura; ; ventricular zone; ; abdominal fat; ; embryo; ; lactiferous duct; ; right adrenal gland;
	Top expressed in
	mandibular prominence; ; dermis; ; left lung lobe; ; human fetus; ; atrium; ; abdominal wall; ; genital tubercle; ; maxillary prominence; ; efferent ductule; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	catalytic activity; hydrolase activity;
Cellular component	integral component of membrane; extracellular exosome; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	mesoderm development; regulation of lipid storage;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4232
	17294
	ENSG00000106484
	ENSMUSG00000051855
	Q5EB52
	Q07646
NM_001253900; NM_001253901; NM_001253902; NM_002402; NM_177524;
	NM_177525
	NM_001252292; NM_001252293; NM_008590
NP_001240829; NP_001240830; NP_001240831; NP_002393; NP_803490;
	NP_803491
	NP_001239221; NP_001239222; NP_032616
	Wikidata
View/Edit Human	View/Edit Mouse

Mesoderm-specific transcript homolog protein is a protein that in humans is encoded by the MEST gene.

This gene encodes a member of the Alpha/beta hydrolase superfamily and has isoform-specific imprinting.

Gene

Three transcript variants encoding two distinct isoforms have been identified for this gene. A pseudogene for this locus is located on chromosome 6.

Function

MEST is highly expressed during embryonic development, particularly in mesoderm-derived tissues, and is implicated in the regulation of fetal growth and differentiation. It is also expressed in the placenta, where it is thought to contribute to nutrient exchange and the establishment of normal growth trajectories.

Clinical significance

The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promoter switching.

In humans, dysregulation of paternal MEST imprinting has been linked to imprinting disorders such as Silver-Russel syndrome, supporting its role in epigenetic control of growth and development.

Animal studies

In animal models, Disruption of MEST expression has been associated with growth abnormalities, including reduced fetal growth and altered adipose development.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000106484 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051855 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nishita Y, Yoshida I, Sado T, Takagi N (February 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics. 36 (3): 539–542. doi:10.1006/geno.1996.0502. PMID 8884280.
1 2 "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".
↑ Kosaki K, Kosaki R, Craigen WJ, Matsuo N (January 2000). "Isoform-specific imprinting of the human PEG1/MEST gene". American Journal of Human Genetics. 66 (1): 309–312. doi:10.1086/302712. PMC 1288335. PMID 10631159.
1 2 Lefebvre L, Viville S, Barton SC, Ishino F, Keverne EB, Surani MA (October 1998). "Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest". Nature Genetics. 20 (2): 163–169. doi:10.1038/2464. PMID 9771709.
↑ Mayer W, Hemberger M, Frank HG, Grümmer R, Winterhager E, Kaufmann P, et al. (January 2000). "Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis". Developmental Dynamics. 217 (1): 1–10. doi:10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4. PMID 10679925.
↑ Eggermann T, Spengler S, Begemann M, Binder G, Buiting K, Albrecht B, et al. (March 2012). "Deletion of the paternal allele of the imprinted MEST/PEG1 region in a patient with Silver-Russell syndrome features". Clinical Genetics. 81 (3): 298–300. doi:10.1111/j.1399-0004.2011.01719.x. PMID 22211632.
↑ Eggermann T, Perez de Nanclares G, Maher ER, Temple IK, Tümer Z, Monk D, et al. (2015). "Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci". Clinical Epigenetics. 7 (1) 123. doi:10.1186/s13148-015-0143-8. PMC 4650860. PMID 26583054.
↑ Kadota Y, Kawakami T, Sato M, Suzuki S (May 2022). "Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes". BMC Research Notes. 15 (1) 164. doi:10.1186/s13104-022-06051-x. PMC 9092885. PMID 35538505.

Kobayashi S, Kohda T, Miyoshi N, Kuroiwa Y, Aisaka K, Tsutsumi O, et al. (May 1997). "Human PEG1/MEST, an imprinted gene on chromosome 7". Human Molecular Genetics. 6 (5): 781–786. doi:10.1093/hmg/6.5.781. PMID 9158153.
Riesewijk AM, Hu L, Schulz U, Tariverdian G, Höglund P, Kere J, et al. (June 1997). "Monoallelic expression of human PEG1/MEST is paralleled by parent-specific methylation in fetuses". Genomics. 42 (2): 236–244. doi:10.1006/geno.1997.4731. hdl:2066/24440. PMID 9192843. S2CID 24034813.
Cuisset L, Le Stunff C, Dupont JM, Vasseur C, Cartigny M, Despert F, et al. (1997). "PEG1 expression in maternal uniparental disomy 7". Annales de Genetique. 40 (4): 211–215. PMID 9526615.
Riesewijk AM, Blagitko N, Schinzel AA, Hu L, Schulz U, Hamel BC, et al. (1998). "Evidence against a major role of PEG1/MEST in Silver-Russell syndrome". European Journal of Human Genetics. 6 (2): 114–120. doi:10.1038/sj.ejhg.5200164. PMID 9781054.
Pedersen IS, Dervan PA, Broderick D, Harrison M, Miller N, Delany E, et al. (November 1999). "Frequent loss of imprinting of PEG1/MEST in invasive breast cancer". Cancer Research. 59 (21): 5449–5451. PMID 10554015.
Hayashida S, Yamasaki K, Asada Y, Soeda E, Niikawa N, Kishino T (June 2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–225. doi:10.1006/geno.2000.6206. PMID 10860668.
Russo S, Bedeschi MF, Cogliati F, Natacci F, Gianotti A, Parini R, et al. (July 2000). "Maternal chromosome 7 hetero/isodisomy in Silver-Russell syndrome and PEG1 biallelic expression". Clinical Dysmorphology. 9 (3): 157–162. doi:10.1097/00019605-200009030-00001. PMID 10955473.
Kerjean A, Dupont JM, Vasseur C, Le Tessier D, Cuisset L, Pàldi A, et al. (September 2000). "Establishment of the paternal methylation imprint of the human H19 and MEST/PEG1 genes during spermatogenesis". Human Molecular Genetics. 9 (14): 2183–2187. doi:10.1093/hmg/9.14.2183. PMID 10958657.
Kohda M, Hoshiya H, Katoh M, Tanaka I, Masuda R, Takemura T, et al. (August 2001). "Frequent loss of imprinting of IGF2 and MEST in lung adenocarcinoma". Molecular Carcinogenesis. 31 (4): 184–191. doi:10.1002/mc.1053. PMID 11536368. S2CID 46249386.
Miozzo M, Grati FR, Bulfamante G, Rossella F, Cribiù M, Radaelli T, et al. (November 2001). "Post-zygotic origin of complete maternal chromosome 7 isodisomy and consequent loss of placental PEG1/MEST expression". Placenta. 22 (10): 813–821. doi:10.1053/plac.2001.0728. PMID 11718568.
Kobayashi S, Uemura H, Kohda T, Nagai T, Chinen Y, Naritomi K, et al. (December 2001). "No evidence of PEG1/MEST gene mutations in Silver-Russell syndrome patients". American Journal of Medical Genetics. 104 (3): 225–231. doi:10.1002/ajmg.10022. PMID 11754049.
Li T, Vu TH, Lee KO, Yang Y, Nguyen CV, Bui HQ, et al. (April 2002). "An imprinted PEG1/MEST antisense expressed predominantly in human testis and in mature spermatozoa". The Journal of Biological Chemistry. 277 (16): 13518–13527. doi:10.1074/jbc.M200458200. PMID 11821432.
Bonora E, Bacchelli E, Levy ER, Blasi F, Marlow A, Monaco AP, et al. (2002). "Mutation screening and imprinting analysis of four candidate genes for autism in the 7q32 region". Molecular Psychiatry. 7 (3): 289–301. doi:10.1038/sj.mp.4001004. PMID 11920156.
Pedersen IS, Dervan P, McGoldrick A, Harrison M, Ponchel F, Speirs V, et al. (June 2002). "Promoter switch: a novel mechanism causing biallelic PEG1/MEST expression in invasive breast cancer". Human Molecular Genetics. 11 (12): 1449–1453. doi:10.1093/hmg/11.12.1449. PMID 12023987.
Nakabayashi K, Bentley L, Hitchins MP, Mitsuya K, Meguro M, Minagawa S, et al. (July 2002). "Identification and characterization of an imprinted antisense RNA (MESTIT1) in the human MEST locus on chromosome 7q32". Human Molecular Genetics. 11 (15): 1743–1756. doi:10.1093/hmg/11.15.1743. PMID 12095916.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000106484 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051855 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Nishita_1997-5] Nishita Y, Yoshida I, Sado T, Takagi N (February 1997). "Genomic imprinting and chromosomal localization of the human MEST gene". Genomics. 36 (3): 539–542. doi:10.1006/geno.1996.0502. PMID 8884280.

[entrez-6] 1 2 "Entrez Gene: MEST mesoderm specific transcript homolog (mouse)".

[7] Kosaki K, Kosaki R, Craigen WJ, Matsuo N (January 2000). "Isoform-specific imprinting of the human PEG1/MEST gene". American Journal of Human Genetics. 66 (1): 309–312. doi:10.1086/302712. PMC 1288335. PMID 10631159.

[Lefebvre_1998-8] 1 2 Lefebvre L, Viville S, Barton SC, Ishino F, Keverne EB, Surani MA (October 1998). "Abnormal maternal behaviour and growth retardation associated with loss of the imprinted gene Mest". Nature Genetics. 20 (2): 163–169. doi:10.1038/2464. PMID 9771709.

[9] Mayer W, Hemberger M, Frank HG, Grümmer R, Winterhager E, Kaufmann P, et al. (January 2000). "Expression of the imprinted genes MEST/Mest in human and murine placenta suggests a role in angiogenesis". Developmental Dynamics. 217 (1): 1–10. doi:10.1002/(SICI)1097-0177(200001)217:1<1::AID-DVDY1>3.0.CO;2-4. PMID 10679925.

[10] Eggermann T, Spengler S, Begemann M, Binder G, Buiting K, Albrecht B, et al. (March 2012). "Deletion of the paternal allele of the imprinted MEST/PEG1 region in a patient with Silver-Russell syndrome features". Clinical Genetics. 81 (3): 298–300. doi:10.1111/j.1399-0004.2011.01719.x. PMID 22211632.

[11] Eggermann T, Perez de Nanclares G, Maher ER, Temple IK, Tümer Z, Monk D, et al. (2015). "Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci". Clinical Epigenetics. 7 (1) 123. doi:10.1186/s13148-015-0143-8. PMC 4650860. PMID 26583054.

[12] Kadota Y, Kawakami T, Sato M, Suzuki S (May 2022). "Mouse mesoderm-specific transcript inhibits adipogenic differentiation and induces trans-differentiation into hepatocyte-like cells in 3T3-L1 preadiocytes". BMC Research Notes. 15 (1) 164. doi:10.1186/s13104-022-06051-x. PMC 9092885. PMID 35538505.