MICAL1

MICAL1

Identifiers

MICAL1, MICAL, MICAL-1, NICAL, microtubule associated monooxygenase, calponin and LIM domain containing 1

External IDs

OMIM: 607129; MGI: 2385847; GeneCards: MICAL1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
1WYL, 2CO8

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
1.6.3.1	↗	↗	↗	↗
1.14.13.225	↗	↗	↗	↗

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)

Band	10\|10 B1	Start	41,352,310 bp
Band	10\|10 B1	End	41,363,028 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right coronary artery

left coronary artery

canal of the cervix

spleen

left uterine tube

popliteal artery

ganglionic eminence

stromal cell of endometrium

right lung

ascending aorta

Top expressed in

granulocyte

lumbar spinal ganglion

ascending aorta

external carotid artery

intestinal villus

internal carotid artery

tunica media of zone of aorta

fossa

Paneth cell

sciatic nerve

More reference expression data


More reference expression data

Gene ontology
Molecular function	SH3 domain binding oxidoreductase activity actin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen FAD binding protein binding metal ion binding protein kinase binding monooxygenase activity NAD(P)H oxidase H2O2-forming activity actin filament binding
Cellular component	cytoplasm cytoskeleton intermediate filament hippocampal mossy fiber expansion cytosol midbody intercellular bridge plasma membrane actin cytoskeleton
Biological process	negative regulation of protein phosphorylation actin filament depolymerization sulfur oxidation negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of apoptotic process cytoskeleton organization signal transduction regulation of regulated secretory pathway blood coagulation
Sources:Amigo / QuickGO

Databases

Species

Human

Mouse


64780


171580


n/a


ENSMUSG00000019823


Q8TDZ2


Q8VDP3

RefSeq (mRNA)


NM_022765 NM_001159291 NM_001286613


NM_001164433 NM_138315 NM_001358838 NM_001358839

RefSeq (protein)


NP_001152763 NP_001273542 NP_073602


NP_001157905 NP_612188 NP_001345767 NP_001345768

Location (UCSC)

n/a

Chr 10: 41.35 – 41.36 Mb

PubMed search

View/Edit Human

View/Edit Mouse

NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene.

Interactions

MICAL1 has been shown to interact with NEDD9 and RAB1A.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019823 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Suzuki T, Nakamoto T, Ogawa S, Seo S, Matsumura T, Tachibana K, Morimoto C, Hirai H (Apr 2002). "MICAL, a novel CasL interacting molecule, associates with vimentin". J Biol Chem. 277 (17): 14933–41. doi:10.1074/jbc.M111842200. PMID 11827972.
↑ "Entrez Gene: MICAL1 microtubule associated monoxygenase, calponin and LIM domain containing 1".
↑ Weide, Thomas; Teuber Julia; Bayer Michael; Barnekow Angelika (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. 306 (1). United States: 79–86. doi:10.1016/S0006-291X(03)00918-5. ISSN 0006-291X. PMID 12788069.

Further reading

Iwata S, Ohashi Y, Kamiguchi K, Morimoto C (2000). "Beta 1-integrin-mediated cell signaling in T lymphocytes". J. Dermatol. Sci. 23 (2): 75–86. doi:10.1016/S0923-1811(99)00096-1. PMID 10808124.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
Terman JR, Mao T, Pasterkamp RJ, et al. (2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. 306 (1): 79–86. doi:10.1016/S0006-291X(03)00918-5. PMID 12788069.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Bayer M, Fischer J, Kremerskothen J, et al. (2006). "Identification and characterization of Iporin as a novel interaction partner for rab1". BMC Cell Biol. 6 (1): 15. doi:10.1186/1471-2121-6-15. PMC 1079803. PMID 15796781.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
Jin X, Zhang J, Dai H, et al. (2007). "Investigation of the four cooperative unfolding units existing in the MICAL-1 CH domain". Biophys. Chem. 129 (2–3): 269–78. doi:10.1016/j.bpc.2007.06.008. PMID 17662518.

PDB gallery

1wyl: Solution structure of the CH domain of human NEDD9 interacting protein with calponin homology and LIM domains
2bra: STRUCTURE OF N-TERMINAL FAD BINDING MOTIF OF MOUSE MICAL
2bry: CRYSTAL STRUCTURE OF THE NATIVE MONOOXYGENASE DOMAIN OF MICAL AT 1.45 A RESOLUTION
2c4c: CRYSTAL STRUCTURE OF THE NADPH-TREATED MONOOXYGENASE DOMAIN OF MICAL
2co8: Solution structures of the LIM domain of human NEDD9 interacting protein with calponin homology and LIM domains
2dk9: Solution structure of Calponin Homology domain of Human MICAL-1

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