MICAL2

MICAL2

Identifiers

MICAL2, MICAL-2, MICAL2PV1, MICAL2PV2, microtubule associated monooxygenase, calponin and LIM domain containing 2

External IDs

OMIM: 608881; MGI: 2444947; GeneCards: MICAL2

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2E9K

Enzyme activity
EC #	BRENDA	ExPASy	KEGG	MetaCyc
1.14.13.225	↗	↗	↗	↗

Gene location (Human)

Chr.	Chromosome 11 (human)

Band	11p15.3	Start	12,094,008 bp
Band	11p15.3	End	12,359,144 bp

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)

Band	7\|7 F1	Start	112,225,856 bp
Band	7\|7 F1	End	112,413,106 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cerebellar hemisphere

right hemisphere of cerebellum

endothelial cell

primary visual cortex

paraflocculus of cerebellum

Brodmann area 23

Descending thoracic aorta

middle temporal gyrus

right coronary artery

saphenous vein

Top expressed in

dentate gyrus of hippocampal formation granule cell

superior frontal gyrus

muscle of thigh

ascending aorta

seminiferous tubule

aortic valve

primary visual cortex

spermatid

cerebellar cortex

atrium

More reference expression data


More reference expression data

Gene ontology
Molecular function	actin binding oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen FAD binding metal ion binding monooxygenase activity oxidoreductase activity NADPH:sulfur oxidoreductase activity NAD(P)H oxidase H2O2-forming activity
Cellular component	nucleus
Biological process	heart looping actin filament depolymerization development of the heart cytoskeleton organization sulfur oxidation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9645


320878


ENSG00000133816


ENSMUSG00000038244


O94851


Q8BML1

RefSeq (mRNA)

NM_001282663 NM_001282664 NM_001282665 NM_001282666 NM_001282667
NM_001282668 NM_001346292 NM_001346293 NM_001346294 NM_001346295 NM_001346296 NM_001346297 NM_001346298 NM_001346299 NM_014632


NM_001193305 NM_177282

RefSeq (protein)

NP_001269592 NP_001269593 NP_001269594 NP_001269595 NP_001269596
NP_001269597 NP_001333221 NP_001333222 NP_001333223 NP_001333224 NP_001333225 NP_001333226 NP_001333227 NP_001333228 NP_055447


NP_001180234 NP_796256

Location (UCSC)

Chr 11: 12.09 – 12.36 Mb

Chr 7: 112.23 – 112.41 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Protein MICAL-2 is a protein that in humans is encoded by the MICAL2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133816 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038244 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Terman JR, Mao T, Pasterkamp RJ, Yu HH, Kolodkin AL (Jul 2002). "MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion". Cell. 109 (7): 887–900. doi:10.1016/S0092-8674(02)00794-8. PMID 12110185.
↑ "Entrez Gene: MICAL2 microtubule associated monoxygenase, calponin and LIM domain containing 2".

Further reading

Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. Res. Commun. 328 (2): 415–23. doi:10.1016/j.bbrc.2004.12.182. PMID 15694364.
Ashida S, Furihata M, Katagiri T, et al. (2006). "Expression of novel molecules, MICAL2-PV (MICAL2 prostate cancer variants), increases with high Gleason score and prostate cancer progression". Clin. Cancer Res. 12 (9): 2767–73. doi:10.1158/1078-0432.CCR-05-1995. PMID 16675569.

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