MLLT3

MLLT3

Identifiers

MLLT3, AF9, YEATS3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, super elongation complex subunit, MLLT3 super elongation complex subunit

External IDs

OMIM: 159558; MGI: 1917372; GeneCards: MLLT3

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LM0, 2MV7, 4TMP, 2N4Q, 5HJB, 5HJD

Gene location (Human)

Chr.	Chromosome 9 (human)

Band	9p21.3	Start	20,341,669 bp
Band	9p21.3	End	20,622,499 bp

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)

Band	4 C4\|4 41.06 cM	Start	87,688,162 bp
Band	4 C4\|4 41.06 cM	End	87,951,601 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

rectum

Achilles tendon

epithelium of colon

endothelial cell

ventricular zone

buccal mucosa cell

testicle

mucosa of transverse colon

stromal cell of endometrium

Top expressed in

tail of embryo

genital tubercle

zygote

metatarsal bones

plantaris muscle

muscle of thigh

extensor digitorum longus muscle

intercostal muscle

Ileal epithelium

triceps brachii muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding chromatin binding histone binding lysine-acetylated histone binding modification-dependent protein binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	transcription elongation factor complex extracellular exosome nucleus nucleoplasm chromosome
Biological process	positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of transcription, DNA-templated negative regulation of canonical Wnt signaling pathway transcription, DNA-templated segment specification anterior/posterior pattern specification transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


4300


70122


ENSG00000171843


ENSMUSG00000028496


P42568


A2AM29

RefSeq (mRNA)


NM_004529 NM_001286691


NM_001286158 NM_027326 NM_029931

RefSeq (protein)


NP_001273620 NP_004520

NP_001273087 NP_081602 NP_084207 NP_001391884 NP_001391885
NP_001391886 NP_001391887

Location (UCSC)

Chr 9: 20.34 – 20.62 Mb

Chr 4: 87.69 – 87.95 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.

Interactions

MLLT3 has been shown to interact with BCOR.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171843 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028496 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nakamura T, Alder H, Gu Y, Prasad R, Canaani O, Kamada N, Gale RP, Lange B, Crist WM, Nowell PC, et al. (Jul 1993). "Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common motifs". Proc Natl Acad Sci U S A. 90 (10): 4631–5. Bibcode:1993PNAS...90.4631N. doi:10.1073/pnas.90.10.4631. PMC 46566. PMID 8506309.
↑ Iida S, Seto M, Yamamoto K, Komatsu H, Tojo A, Asano S, Kamada N, Ariyoshi Y, Takahashi T, Ueda R (Nov 1993). "MLLT3 gene on 9p22 involved in t(9;11) leukemia encodes a serine/proline rich protein homologous to MLLT1 on 19p13". Oncogene. 8 (11): 3085–92. PMID 8414510.
↑ "Entrez Gene: MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3".
↑ Srinivasan, R Sathish; de Erkenez Andrea C; Hemenway Charles S (May 2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. ISSN 0950-9232. PMID 12776190.

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Huynh KD, Fischle W, Verdin E, Bardwell VJ (2000). "BCoR, a novel corepressor involved in BCL-6 repression". Genes Dev. 14 (14): 1810–23. doi:10.1101/gad.14.14.1810. PMC 316791. PMID 10898795.
García-Cuéllar MP, Zilles O, Schreiner SA, et al. (2001). "The ENL moiety of the childhood leukemia-associated MLL-ENL oncoprotein recruits human Polycomb 3". Oncogene. 20 (4): 411–9. doi:10.1038/sj.onc.1204108. PMID 11313972.
Hemenway CS, de Erkenez AC, Gould GC (2001). "The polycomb protein MPc3 interacts with AF9, an MLL fusion partner in t(9;11)(p22;q23) acute leukemias". Oncogene. 20 (29): 3798–805. doi:10.1038/sj.onc.1204478. PMID 11439343.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Srinivasan RS, de Erkenez AC, Hemenway CS (2003). "The mixed lineage leukemia fusion partner AF9 binds specific isoforms of the BCL-6 corepressor". Oncogene. 22 (22): 3395–406. doi:10.1038/sj.onc.1206361. PMID 12776190.
Erfurth F, Hemenway CS, de Erkenez AC, Domer PH (2004). "MLL fusion partners AF4 and AF9 interact at subnuclear foci". Leukemia. 18 (1): 92–102. doi:10.1038/sj.leu.2403200. PMID 14603337.
Montemurro L, Tonelli R, Fazzina R, et al. (2004). "Identification of two MLL-MLLT3 (alias MLL-AF9) chimeric transcripts in the MOLM-13 cell line". Cancer Genet. Cytogenet. 154 (1): 96–7. doi:10.1016/j.cancergencyto.2004.01.029. PMID 15381384.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Martino V, Tonelli R, Montemurro L, et al. (2006). "Down-regulation of MLL-AF9, MLL and MYC expression is not obligatory for monocyte-macrophage maturation in AML-M5 cell lines carrying t(9;11)(p22;q23)". Oncol. Rep. 15 (1): 207–11. doi:10.3892/or.15.1.207. PMID 16328057.

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