MLLT3

MLLT3
Identifiers
Aliases	MLLT3, AF9, YEATS3, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3, super elongation complex subunit, MLLT3 super elongation complex subunit
External IDs	OMIM: 159558; MGI: 1917372; GeneCards: MLLT3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LM0, 2MV7, 4TMP, 2N4Q, 5HJB, 5HJD
Gene location (Human) Chr. Chromosome 9 (human) Band 9p21.3 Start 20,341,669 bp End 20,622,499 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 C4|4 41.06 cM Start 87,688,162 bp End 87,951,601 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence rectum Achilles tendon epithelium of colon endothelial cell ventricular zone buccal mucosa cell testicle mucosa of transverse colon stromal cell of endometrium Top expressed in tail of embryo genital tubercle zygote metatarsal bones plantaris muscle muscle of thigh extensor digitorum longus muscle intercostal muscle Ileal epithelium triceps brachii muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding chromatin binding histone binding lysine-acetylated histone binding modification-dependent protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription elongation factor complex extracellular exosome nucleus nucleoplasm chromosome Biological process positive regulation of Wnt signaling pathway, planar cell polarity pathway regulation of transcription, DNA-templated negative regulation of canonical Wnt signaling pathway transcription, DNA-templated segment specification anterior/posterior pattern specification transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter positive regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 4300 70122 Ensembl ENSG00000171843 ENSMUSG00000028496 UniProt P42568 A2AM29 RefSeq (mRNA) NM_004529 NM_001286691 NM_001286158 NM_027326 NM_029931 RefSeq (protein) NP_001273620 NP_004520 NP_001273087 NP_081602 NP_084207 NP_001391884 NP_001391885 NP_001391886 NP_001391887 Location (UCSC) Chr 9: 20.34 – 20.62 Mb Chr 4: 87.69 – 87.95 Mb PubMed search
Wikidata
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Protein AF-9 is a protein that in humans is encoded by the MLLT3 gene.

Interactions

MLLT3 has been shown to interact with BCOR.