Fatty acyl-CoA reductase 1

FAR1
Identifiers
Aliases	FAR1, MLSTD2, SDR10E1, PFCRD, fatty acyl-CoA reductase 1, CSPSD
External IDs	OMIM: 616107; MGI: 1914670; GeneCards: FAR1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	13,732,346 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	113,170,718 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; jejunal mucosa; ; oral cavity; ; monocyte; ; spinal cord; ; C1 segment; ; rectum; ; bone marrow cell; ; subthalamic nucleus; ; inferior ganglion of vagus nerve;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; granulocyte; ; transitional epithelium of urinary bladder; ; substantia nigra; ; mammillary body; ; proximal tubule; ; mucous cell of stomach; ; right kidney; ; cumulus cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	fatty-acyl-CoA reductase (alcohol-forming) activity; oxidoreductase activity; alcohol-forming fatty acyl-CoA reductase activity;
Cellular component	integral component of membrane; peroxisomal membrane; peroxisome; peroxisomal matrix; membrane; integral component of peroxisomal membrane;
Biological process	glycerophospholipid biosynthetic process; long-chain fatty-acyl-CoA metabolic process; lipid metabolism; ether lipid biosynthetic process; wax biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84188
	67420
	ENSG00000197601
	ENSMUSG00000030759
	Q8WVX9
	Q922J9
	NM_032228
	NM_001285831; NM_026143; NM_027379; NM_001360668; NM_001360669
	NP_115604
	NP_001272760; NP_081655; NP_001347597; NP_001347598
	Wikidata
View/Edit Human	View/Edit Mouse

Fatty acyl-CoA reductase 1 is an enzyme that in humans is encoded by the FAR1 gene. This enzyme produces fatty alcohols from 16 or 18 carbon fatty acyl-CoA and 2 copies of NADPH. These fatty alcohols are needed for the production of ether lipids and wax esters. Unlike its paralog, FAR2, FAR1 is able to not only act on saturated fatty acids, but also unsaturated fatty acids. FAR1 is part of the alcohol-forming fatty acyl-CoA reductase class of enzymes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197601 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030759 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cheng JB, Russell DW (Aug 2004). "Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions". J Biol Chem. 279 (36): 37789–97. doi:10.1074/jbc.M406225200. PMC 2757098. PMID 15220348.
↑ Cheng JB, Russell DW (Aug 2004). "Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family". J Biol Chem. 279 (36): 37798–807. doi:10.1074/jbc.M406226200. PMC 2743083. PMID 15220349.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
↑ "Entrez Gene: MLSTD2 male sterility domain containing 2".
1 2 3 4 "Q8WVX9 · FACR1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-07.
↑ "Q96K12 · FACR2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-07.

Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Foster LJ, Rudich A, Talior I, et al. (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197601 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030759 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15220348-5] Cheng JB, Russell DW (Aug 2004). "Mammalian wax biosynthesis. I. Identification of two fatty acyl-Coenzyme A reductases with different substrate specificities and tissue distributions". J Biol Chem. 279 (36): 37789–97. doi:10.1074/jbc.M406225200. PMC 2757098. PMID 15220348.

[pmid15220349-6] Cheng JB, Russell DW (Aug 2004). "Mammalian wax biosynthesis. II. Expression cloning of wax synthase cDNAs encoding a member of the acyltransferase enzyme family". J Biol Chem. 279 (36): 37798–807. doi:10.1074/jbc.M406226200. PMC 2743083. PMID 15220349.

[pmid19027726-7] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-8] "Entrez Gene: MLSTD2 male sterility domain containing 2".

[uniprot-9] 1 2 3 4 "Q8WVX9 · FACR1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-07.

[10] "Q96K12 · FACR2_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-09-07.

Fatty acyl-CoA reductase 1

References

Further reading