ML domain

Available protein structures:
PDB	IPR003172 PF02221 (ECOD; PDBsum)
AlphaFold	IPR003172; PF02221;

ML domain
ML domain
	X-ray structure of Der p 2, the major house dust mite allergen
Identifiers
Symbol	E1_DerP2_DerF2
Pfam	PF02221
InterPro	IPR003172
SCOP2	1a9v / SCOPe / SUPFAM
OPM superfamily	91
OPM protein	1nep
CDD	cd00912
PDB
Available protein structures:
PDB	IPR003172 PF02221 (ECOD; PDBsum)
AlphaFold	IPR003172; PF02221;

The MD-2-related lipid-recognition (ML) domain is implicated in lipid recognition, particularly in the recognition of pathogen related products. It has an immunoglobulin-like beta-sandwich fold similar to that of immunoglobulin E-set domains. This domain is present in the following proteins:

Epididymal secretory protein E1 (also known as Niemann-Pick C2 protein), which is known to bind cholesterol. Niemann-Pick disease type C2 is a fatal hereditary disease characterised by accumulation of low-density lipoprotein-derived cholesterol in lysosomes.
House dust mite allergen proteins such as Der f 2 from Dermatophagoides farinae and Der p 2 from Dermatophagoides pteronyssinus.

Human proteins containing this domain

LY86; LY96; MMD-1;

References

↑ Lobel P, Stock AM, Friedland N, Liou HL (2003). "Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2512–2517. Bibcode:2003PNAS..100.2512F. doi:10.1073/pnas.0437840100. PMC 151372. PMID 12591954.
↑ Kristensen O, Kastrup JS, Skov LK, Gajhede M, Larsen JN, Johannessen BR, Bolwig C, Spangfort M, Lund K (2005). "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity". FEBS Lett. 579 (5): 1208–12. Bibcode:2005FEBSL.579.1208J. doi:10.1016/j.febslet.2004.11.115. PMID 15710415. S2CID 30079878.

This article incorporates text from the public domain Pfam and InterPro: IPR003172

[PUB00029036-1] Lobel P, Stock AM, Friedland N, Liou HL (2003). "Structure of a cholesterol-binding protein deficient in Niemann-Pick type C2 disease". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2512–2517. Bibcode:2003PNAS..100.2512F. doi:10.1073/pnas.0437840100. PMC 151372. PMID 12591954.

[PUB00032538-2] Kristensen O, Kastrup JS, Skov LK, Gajhede M, Larsen JN, Johannessen BR, Bolwig C, Spangfort M, Lund K (2005). "Structure of the house dust mite allergen Der f 2: implications for function and molecular basis of IgE cross-reactivity". FEBS Lett. 579 (5): 1208–12. Bibcode:2005FEBSL.579.1208J. doi:10.1016/j.febslet.2004.11.115. PMID 15710415. S2CID 30079878.