MOB kinase activator 1A

MOB1A
Identifiers
Aliases	MOB1A, C2orf6, MATS1, MOB1, MOBK1B, MOBKL1B, Mob4B, MOB kinase activator 1A, MABKL1B
External IDs	OMIM: 609281; MGI: 2442631; GeneCards: MOB1A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4J1V, 4JIZ, 5BRK, 5BRM
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,178,898 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,320,758 bp
RNA expression pattern
	Top expressed in
	monocyte; ; epithelium of nasopharynx; ; superficial temporal artery; ; secondary oocyte; ; bone marrow cell; ; lymph node; ; cecum; ; appendix; ; hair follicle; ; palpebral conjunctiva;
	Top expressed in
	Ileal epithelium; ; mesenteric lymph nodes; ; corneal stroma; ; granulocyte; ; stroma of bone marrow; ; Paneth cell; ; gastrula; ; endothelial cell of lymphatic vessel; ; spleen; ; genital tubercle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	metal ion binding; protein binding;
Cellular component	extracellular exosome; nucleus; nucleolus; cytosol;
Biological process	hippo signaling;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55233
	232157
	ENSG00000114978
	ENSMUSG00000043131
	Q9H8S9
	Q921Y0
	NM_018221; NM_001317110; NM_001317111; NM_001317112
	NM_145571
	NP_001304039; NP_001304040; NP_001304041; NP_060691
	NP_663546
	Wikidata
View/Edit Human	View/Edit Mouse

MOB kinase activator 1A is an enzyme that in humans is encoded by the MOB1A gene (previously MOBK1B). This protein is part of the hippo signaling pathway.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000114978 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043131 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.
1 2 "Entrez Gene: MOB kinase activator 1A".

Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (May 2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nature Biotechnology. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
Stavridi ES, Harris KG, Huyen Y, Bothos J, Verwoerd PM, Stayrook SE, Pavletich NP, Jeffrey PD, Luca FC (Sep 2003). "Crystal structure of a human Mob1 protein: toward understanding Mob-regulated cell cycle pathways". Structure. 11 (9): 1163–70. doi:10.1016/S0969-2126(03)00182-5. PMID 12962634.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (Aug 2004). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". The Journal of Biological Chemistry. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Lai ZC, Wei X, Shimizu T, Ramos E, Rohrbaugh M, Nikolaidis N, Ho LL, Li Y (Mar 2005). "Control of cell proliferation and apoptosis by mob as tumor suppressor, mats". Cell. 120 (5): 675–85. doi:10.1016/j.cell.2004.12.036. PMID 15766530. S2CID 13785447.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Kosaka Y, Mimori K, Tanaka F, Inoue H, Watanabe M, Mori M (Aug 2007). "Clinical significance of the loss of MATS1 mRNA expression in colorectal cancer". International Journal of Oncology. 31 (2): 333–8. doi:10.3892/ijo.31.2.333. PMID 17611689.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human MOB kinase activator 1A

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000114978 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000043131 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11319234-5] Moreno CS, Lane WS, Pallas DC (Jun 2001). "A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes". The Journal of Biological Chemistry. 276 (26): 24253–60. doi:10.1074/jbc.M102398200. PMC 3503316. PMID 11319234.

[entrez-6] 1 2 "Entrez Gene: MOB kinase activator 1A".

MOB kinase activator 1A

References

Further reading

External links