MORC3

MORC3
Identifiers
Aliases	MORC3, NXP2, ZCW5, ZCWCC3, MORC family CW-type zinc finger 3
External IDs	OMIM: 610078; MGI: 2136841; GeneCards: MORC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QQ4
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,386,148 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,672,961 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; paraflocculus of cerebellum; ; middle frontal gyrus; ; epithelium of nasopharynx; ; epithelium of colon; ; Brodmann area 10; ; mucosa of paranasal sinus; ; frontal pole; ; gingival epithelium; ; palpebral conjunctiva;
	Top expressed in
	spermatocyte; ; primitive streak; ; lymph node; ; otic placode; ; mesenteric lymph nodes; ; granulocyte; ; tail of embryo; ; genital tubercle; ; conjunctival fornix; ; otic vesicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; RNA binding; protein binding;
Cellular component	nuclear matrix; PML body; nucleus; nucleoplasm;
Biological process	protein phosphorylation; protein stabilization; viral process; negative regulation of fibroblast proliferation; post-embryonic development; peptidyl-serine phosphorylation; maintenance of protein location in nucleus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23515
	338467
	ENSG00000159256
	ENSMUSG00000039456
	Q14149
	F7BJB9
	NM_015358; NM_001320445; NM_001320446
	NM_001045529
	NP_001307374; NP_001307375; NP_056173
	NP_001038994
	Wikidata
View/Edit Human	View/Edit Mouse

MORC family CW-type zinc finger protein 3 is a protein that in humans is encoded by the MORC3 gene.

This gene encodes a protein that localizes to the nuclear matrix. The protein also has RNA binding activity, and has a predicted coiled-coil domain.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159256 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039456 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.
1 2 "Entrez Gene: MORC3 MORC family CW-type zinc finger 3".

Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Kimura Y, Sakai F, Nakano O, et al. (2002). "The newly identified human nuclear protein NXP-2 possesses three distinct domains, the nuclear matrix-binding, RNA-binding, and coiled-coil domains". J. Biol. Chem. 277 (23): 20611–7. doi:10.1074/jbc.M201440200. PMID 11927593.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Rosendorff A, Sakakibara S, Lu S, et al. (2006). "NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5308–13. Bibcode:2006PNAS..103.5308R. doi:10.1073/pnas.0601066103. PMC 1459351. PMID 16567619.
Takahashi K, Yoshida N, Murakami N, et al. (2007). "Dynamic regulation of p53 subnuclear localization and senescence by MORC3". Mol. Biol. Cell. 18 (5): 1701–9. doi:10.1091/mbc.E06-08-0747. PMC 1855011. PMID 17332504.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159256 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14607086-5] Perry J, Zhao Y (Nov 2003). "The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants". Trends Biochem Sci. 28 (11): 576–80. doi:10.1016/j.tibs.2003.09.007. PMID 14607086.

[entrez-6] 1 2 "Entrez Gene: MORC3 MORC family CW-type zinc finger 3".

MORC3

See also

References

Further reading