MORF4L2

MORF4L2

Identifiers

MORF4L2, MORFL2, MRGX, mortality factor 4 like 2

External IDs

OMIM: 300409; MGI: 1927167; GeneCards: MORF4L2

Gene location (Human)

Chr.	X chromosome (human)

Band	Xq22.2	Start	103,675,496 bp
Band	Xq22.2	End	103,688,158 bp

Gene location (Mouse)

Chr.	X chromosome (mouse)

Band	X\|X F1	Start	135,633,691 bp
Band	X\|X F1	End	135,644,439 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

endothelial cell

Epithelium of choroid plexus

caput epididymis

bronchial epithelial cell

pons

tail of epididymis

postcentral gyrus

Brodmann area 23

seminal vesicula

corpus epididymis

Top expressed in

yolk sac

placenta

mesencephalon

neural tube

lens

epiblast

islet of Langerhans

uterus

ventricular zone

dentate gyrus of hippocampal formation granule cell

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	plasma membrane nucleolus nucleus nucleoplasm NuA4 histone acetyltransferase complex histone acetyltransferase complex
Biological process	histone H2A acetylation chromatin remodeling regulation of growth regulation of transcription, DNA-templated histone deacetylation DNA repair transcription, DNA-templated positive regulation of transcription by RNA polymerase II positive regulation of striated muscle cell differentiation cellular response to DNA damage stimulus histone H4 acetylation chromatin organization histone acetylation
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9643


56397


ENSG00000123562


ENSMUSG00000031422


Q15014


Q9R0Q4

RefSeq (mRNA)

NM_012286 NM_001142418 NM_001142419 NM_001142420 NM_001142421
NM_001142422 NM_001142423 NM_001142424 NM_001142425 NM_001142426 NM_001142427 NM_001142428 NM_001142429 NM_001142430 NM_001142431 NM_001142432

NM_001168225 NM_001168226 NM_001168227 NM_001168228 NM_001168229
NM_001168230 NM_019768

RefSeq (protein)

NP_001135890 NP_001135891 NP_001135892 NP_001135893 NP_001135894
NP_001135895 NP_001135896 NP_001135897 NP_001135898 NP_001135899 NP_001135900 NP_001135901 NP_001135902 NP_001135903 NP_001135904 NP_036418

NP_001161697 NP_001161698 NP_001161699 NP_001161700 NP_001161701
NP_001161702 NP_062742

Location (UCSC)

Chr X: 103.68 – 103.69 Mb

Chr X: 135.63 – 135.64 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Mortality factor 4-like protein 2 is a protein that in humans is encoded by the MORF4L2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000123562 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031422 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Bertram MJ, Berube NG, Hang-Swanson X, Ran Q, Leung JK, Bryce S, Spurgers K, Bick RJ, Baldini A, Ning Y, Clark LJ, Parkinson EK, Barrett JC, Smith JR, Pereira-Smith OM (Feb 1999). "Identification of a Gene That Reverses the Immortal Phenotype of a Subset of Cells and Is a Member of a Novel Family of Transcription Factor-Like Genes". Mol Cell Biol. 19 (2): 1479–85. doi:10.1128/mcb.19.2.1479. PMC 116076. PMID 9891081.
↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
↑ "Entrez Gene: MORF4L2 mortality factor 4 like 2".

Further reading

Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID 10942595.
Sakai K, Shirakawa T, Li Y, et al. (2002). "Interaction of a paraneoplastic cerebellar degeneration-associated neuronal protein with the nuclear helix-loop-helix leucine zipper protein MRG X". Mol. Cell. Neurosci. 19 (4): 477–84. doi:10.1006/mcne.2001.1059. PMID 11988016. S2CID 26659745.
Yochum GS, Ayer DE (2002). "Role for the Mortality Factors MORF4, MRGX, and MRG15 in Transcriptional Repression via Associations with Pf1, mSin3A, and Transducin-Like Enhancer of Split". Mol. Cell. Biol. 22 (22): 7868–76. doi:10.1128/MCB.22.22.7868-7876.2002. PMC 134742. PMID 12391155.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cai Y, Jin J, Tomomori-Sato C, et al. (2003). "Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex". J. Biol. Chem. 278 (44): 42733–6. doi:10.1074/jbc.C300389200. PMID 12963728.
Tominaga K, Leung JK, Rookard P, et al. (2004). "MRGX is a novel transcriptional regulator that exhibits activation or repression of the B-myb promoter in a cell type-dependent manner". J. Biol. Chem. 278 (49): 49618–24. doi:10.1074/jbc.M309192200. PMID 14506250.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Cai Y, Jin J, Florens L, et al. (2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. Biol. Chem. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

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