MPDU1

MPDU1

Identifiers

MPDU1, CDGIF, HBEBP2BPA, Lec35, My008, PP3958, PQLC5, SL15, mannose-P-dolichol utilization defect 1, SLC66A5

External IDs

OMIM: 604041; MGI: 1346040; GeneCards: MPDU1

Gene location (Human)

Chr.	Chromosome 17 (human)

Band	17p13.1	Start	7,583,529 bp
Band	17p13.1	End	7,592,789 bp

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)

Band	11 B3\|11 42.86 cM	Start	69,547,523 bp
Band	11 B3\|11 42.86 cM	End	69,553,468 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

rectum

mucosa of transverse colon

islet of Langerhans

right lobe of liver

right adrenal cortex

left adrenal gland

left adrenal cortex

granulocyte

gallbladder

body of stomach

Top expressed in

yolk sac

neural layer of retina

lip

right kidney

morula

morula

granulocyte

ventricular zone

ankle joint

duodenum

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding
Cellular component	integral component of membrane extracellular exosome endoplasmic reticulum membrane membrane mitochondrion endoplasmic reticulum
Biological process	dolichol-linked oligosaccharide biosynthetic process oligosaccharide biosynthetic process protein folding transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9526


24070


ENSG00000129255


ENSMUSG00000018761


O75352


Q9R0Q9

RefSeq (mRNA)


NM_004870 NM_001330073


NM_001301710 NM_001301711 NM_011900

RefSeq (protein)


NP_001317002 NP_004861


n/a

Location (UCSC)

Chr 17: 7.58 – 7.59 Mb

Chr 11: 69.55 – 69.55 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Mannose-P-dolichol utilization defect 1 protein is a protein that in humans is encoded by the MPDU1 gene.

See also

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129255 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000018761 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ware FE, Lehrman MA (Aug 1996). "Expression cloning of a novel suppressor of the Lec15 and Lec35 glycosylation mutations of Chinese hamster ovary cells". J Biol Chem. 271 (24): 13935–8. doi:10.1074/jbc.271.24.13935. PMID 8663248.
↑ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. Bibcode:1998PNAS...95.8175M. doi:10.1073/pnas.95.14.8175. PMC 20949. PMID 9653160.
↑ Schenk B, Imbach T, Frank CG, Grubenmann CE, Raymond GV, Hurvitz H, Korn-Lubetzki I, Revel-Vik S, Raas-Rotschild A, Luder AS, Jaeken J, Berger EG, Matthijs G, Hennet T, Aebi M (Dec 2001). "MPDU1 mutations underlie a novel human congenital disorder of glycosylation, designated type If". J Clin Invest. 108 (11): 1687–95. doi:10.1172/JCI13419. PMC 200989. PMID 11733564.
↑ "Entrez Gene: MPDU1 mannose-P-dolichol utilization defect 1".

Further reading

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Anand M, Rush JS, Ray S, et al. (2001). "Requirement of the Lec35 gene for all known classes of monosaccharide-P-dolichol-dependent glycosyltransferase reactions in mammals". Mol. Biol. Cell. 12 (2): 487–501. doi:10.1091/mbc.12.2.487. PMC 30958. PMID 11179430.
Kranz C, Denecke J, Lehrman MA, et al. (2002). "A mutation in the human MPDU1 gene causes congenital disorder of glycosylation type If (CDG-If)". J. Clin. Invest. 108 (11): 1613–9. doi:10.1172/JCI13635. PMC 200991. PMID 11733556.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

External links

GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Overview

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