MPZL1

MPZL1

Identifiers

MPZL1, MPZL1b, PZR, PZR1b, PZRa, PZRb, myelin protein zero like 1

External IDs

OMIM: 604376; MGI: 1915731; GeneCards: MPZL1

Gene location (Human)

Chr.	Chromosome 1 (human)

Band	1q24.2	Start	167,721,192 bp
Band	1q24.2	End	167,791,919 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1\|1 H2.3	Start	165,419,809 bp
Band	1\|1 H2.3	End	165,462,107 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

stromal cell of endometrium

gallbladder

rectum

smooth muscle tissue

minor salivary glands

islet of Langerhans

left uterine tube

gastric mucosa

epithelium of colon

right coronary artery

Top expressed in

otolith organ

utricle

hand

vestibular sensory epithelium

cervix

external carotid artery

vas deferens

Gonadal ridge

superior cervical ganglion

internal carotid artery

More reference expression data


More reference expression data

Gene ontology
Molecular function	protein binding structural molecule activity
Cellular component	integral component of membrane cell surface integral component of plasma membrane membrane focal adhesion
Biological process	cell-cell signaling signal transduction transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell migration
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


9019


68481


ENSG00000197965


ENSMUSG00000026566


O95297


Q3TEW6

RefSeq (mRNA)


NM_024569 NM_001146191 NM_003953


NM_001001880 NM_001083897 NM_001347128

RefSeq (protein)


NP_001139663 NP_003944 NP_078845 NP_003944.1


NP_001001880 NP_001077366 NP_001334057

Location (UCSC)

Chr 1: 167.72 – 167.79 Mb

Chr 1: 165.42 – 165.46 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Myelin protein zero-like protein 1 is a protein that in humans is encoded by the MPZL1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197965 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026566 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhao ZJ, Zhao R (Dec 1998). "Purification and cloning of PZR, a binding protein and putative physiological substrate of tyrosine phosphatase SHP-2". J Biol Chem. 273 (45): 29367–72. doi:10.1074/jbc.273.45.29367. PMID 9792637.
↑ "Entrez Gene: MPZL1 myelin protein zero-like 1".

Further reading

Zhao R, Zhao ZJ (2000). "Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs". J. Biol. Chem. 275 (8): 5453–9. doi:10.1074/jbc.275.8.5453. PMID 10681522.
Zhao R, Guerrah A, Tang H, Zhao ZJ (2002). "Cell surface glycoprotein PZR is a major mediator of concanavalin A-induced cell signaling". J. Biol. Chem. 277 (10): 7882–8. doi:10.1074/jbc.M111914200. PMID 11751924.
Tang DS, Yu KP, Tang XX, et al. (2000). "Cloning of Human Myelin Protein Zero-like Genes by Bioinformatics Strategy". Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao Acta Biochimica et Biophysica Sinica. 32 (4): 364–368. PMID 12075424.
Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants". Mol. Vis. 8: 205–20. PMID 12107410.
Zannettino AC, Roubelakis M, Welldon KJ, et al. (2003). "Novel mesenchymal and haematopoietic cell isoforms of the SHP-2 docking receptor, PZR: identification, molecular cloning and effects on cell migration". Biochem. J. 370 (Pt 2): 537–49. doi:10.1042/BJ20020935. PMC 1223174. PMID 12410637.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhao R, Zhao ZJ (2003). "Identification of a variant form of PZR lacking immunoreceptor tyrosine-based inhibitory motifs". Biochem. Biophys. Res. Commun. 303 (4): 1028–33. doi:10.1016/S0006-291X(03)00484-4. PMID 12684038.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Blanchetot C, Chagnon M, Dubé N, et al. (2005). "Substrate-trapping techniques in the identification of cellular PTP targets". Methods. 35 (1): 44–53. doi:10.1016/j.ymeth.2004.07.007. PMID 15588985.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
He G, Liu X, Qin W, et al. (2006). "MPZL1/PZR, a novel candidate predisposing schizophrenia in Han Chinese". Mol. Psychiatry. 11 (8): 748–51. doi:10.1038/sj.mp.4001841. PMID 16702974.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

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