Mitochondrial ribosomal protein S9

MRPS9
Identifiers
Aliases	MRPS9, MRP-S9, RPMS9, S9mt, mitochondrial ribosomal protein S9
External IDs	OMIM: 611975; MGI: 1916777; GeneCards: MRPS9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Gene location (Human) Chr. Chromosome 2 (human) Band 2q12.1 Start 105,038,069 bp End 105,099,960 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 B Start 42,890,393 bp End 42,944,843 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle gastrocnemius muscle deltoid muscle tibialis anterior muscle quadriceps femoris muscle vastus lateralis muscle muscle of thigh apex of heart mucosa of transverse colon Skeletal muscle tissue of rectus abdominis Top expressed in Paneth cell medullary collecting duct atrioventricular junction fossa atrioventricular valve soleus muscle condyle endocardial cushion myocardium of ventricle epithelium of lens More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome nucleolus mitochondrial small ribosomal subunit mitochondrion Biological process maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 64965 69527 Ensembl ENSG00000135972 ENSMUSG00000060679 UniProt P82933 Q9D7N3 RefSeq (mRNA) NM_182640 NM_023514 RefSeq (protein) NP_872578 NP_076003 Location (UCSC) Chr 2: 105.04 – 105.1 Mb Chr 1: 42.89 – 42.94 Mb PubMed search
Wikidata
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Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene.

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. [provided by RefSeq, Jul 2008].

See also

• Mitochondrial ribosome

References

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: P82933 (Human 28S ribosomal protein S9, mitochondrial (MRPS9)) at the PDBe-KB.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.