MTFP1

MTFP1
Identifiers
Aliases	MTFP1, MTP18, HSPC242, mitochondrial fission process 1
External IDs	OMIM: 610235; MGI: 1916686; GeneCards: MTFP1
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,429,054 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,045,445 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; apex of heart; ; human kidney; ; gonad; ; left ventricle; ; renal cortex; ; gastrocnemius muscle; ; right auricle of heart; ; right lobe of liver; ; testicle;
	Top expressed in
	interventricular septum; ; digastric muscle; ; myocardium of ventricle; ; subiculum; ; soleus muscle; ; extraocular muscle; ; sternocleidomastoid muscle; ; anterior amygdaloid area; ; temporal muscle; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	51537
	67900
	ENSG00000242114
	ENSMUSG00000004748
	Q9UDX5
	Q9CRB8
	NM_016498; NM_001003704
	NM_026443
	NP_001003704; NP_057582
	NP_080719
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial fission process protein 1 is a protein that in humans is encoded by the MTFP1 gene (previously MTP18). This protein acts to inhibit the fusion of mitochondria. This functions as a quality control mechanism that prevents defective inner mitochondrial membranes from undergoing fusion with other mitochondria.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000242114 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004748 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MTP18 mitochondrial protein 18 kDa".
1 2 "Q9UDX5 · MTFP1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–1560. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
Tondera D, Santel A, Schwarzer R, Dames S, Giese K, Klippel A, et al. (July 2004). "Knockdown of MTP18, a novel phosphatidylinositol 3-kinase-dependent protein, affects mitochondrial morphology and induces apoptosis". The Journal of Biological Chemistry. 279 (30): 31544–31555. doi:10.1074/jbc.M404704200. PMID 15155745.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, Dike S, Brubaker S, Patel S, et al. (May 2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725). New York, N.Y.: 1149–1154. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Kapranov P, Drenkow J, Cheng J, Long J, Helt G, Dike S, et al. (July 2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Research. 15 (7): 987–997. doi:10.1101/gr.3455305. PMC 1172043. PMID 15998911.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000242114 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000004748 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MTP18 mitochondrial protein 18 kDa".

[uniprot-6] 1 2 "Q9UDX5 · MTFP1_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

MTFP1

References

Further reading