MTPN

MTPN

Identifiers

MTPN, GCDP, V-1, myotrophin

External IDs

OMIM: 606484; MGI: 99445; GeneCards: MTPN

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
3AAA

Gene location (Human)

Chr.	Chromosome 7 (human)

Band	7q33	Start	135,926,760 bp
Band	7q33	End	135,977,359 bp

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)

Band	6\|6 B1	Start	35,485,841 bp
Band	6\|6 B1	End	35,516,823 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

cardiac muscle tissue of right atrium

skin of arm

mucosa of ileum

myocardium of left ventricle

superficial temporal artery

monocyte

lower lobe of lung

trabecular bone

Brodmann area 46

tibialis anterior muscle

Top expressed in

retinal pigment epithelium

Rostral migratory stream

barrel cortex

ciliary body

epithelium of lens

dorsal striatum

endothelial cell of lymphatic vessel

subiculum

prefrontal cortex

pineal gland

More reference expression data


More reference expression data

Gene ontology
Molecular function	sequence-specific DNA binding
Cellular component	cytoplasm F-actin capping protein complex axon perinuclear region of cytoplasm nucleus cytosol
Biological process	regulation of striated muscle tissue development catecholamine metabolic process positive regulation of cardiac muscle hypertrophy regulation of barbed-end actin filament capping cellular response to mechanical stimulus skeletal muscle tissue regeneration neuron differentiation striated muscle cell differentiation regulation of translation cerebellar granule cell differentiation positive regulation of NF-kappaB transcription factor activity positive regulation of cell growth positive regulation of macromolecule biosynthetic process regulation of cell size
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


136319


14489


ENSG00000105887


ENSMUSG00000029840


P58546


P62774

RefSeq (mRNA)


NM_145808


NM_008098

RefSeq (protein)


NP_665807


NP_032124

Location (UCSC)

Chr 7: 135.93 – 135.98 Mb

Chr 6: 35.49 – 35.52 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Myotrophin is a protein that in humans is encoded by the MTPN gene.

Interactions

MTPN has been shown to interact with RELA and REL.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105887 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029840 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mitra S, Timur AA, Gupta S, Wang Q, Sen S (July 2001). "Assignment of myotrophin to human chromosome band 7q33→q35 by in situ hybridization". Cytogenet Cell Genet. 93 (1–2): 151–2. doi:10.1159/000056974. PMID 11474205. S2CID 30646120.
↑ "Entrez Gene: MTPN myotrophin".
1 2 Knuefermann, Pascal; Chen Peter; Misra Arunima; Shi Shu-Ping; Abdellatif Maha; Sivasubramanian Natarajan (June 2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26). United States: 23888–97. doi:10.1074/jbc.M202937200. ISSN 0021-9258. PMID 11971907.

Further reading

Taoka M, Yamakuni T, Song SY, et al. (1992). "A rat cerebellar protein containing the cdc10/SWI6 motif". Eur. J. Biochem. 207 (2): 615–20. doi:10.1111/j.1432-1033.1992.tb17088.x. PMID 1633812.
Sil P, Misono K, Sen S (1993). "Myotrophin in human cardiomyopathic heart". Circ. Res. 73 (1): 98–108. doi:10.1161/01.res.73.1.98. PMID 8508536.
Sivasubramanian N, Adhikary G, Sil PC, Sen S (1996). "Cardiac myotrophin exhibits rel/NF-kappa B interacting activity in vitro". J. Biol. Chem. 271 (5): 2812–6. doi:10.1074/jbc.271.5.2812. PMID 8576259.
Anderson KM, Berrebi-Bertrand I, Kirkpatrick RB, et al. (1999). "cDNA sequence and characterization of the gene that encodes human myotrophin/V-1 protein, a mediator of cardiac hypertrophy". J. Mol. Cell. Cardiol. 31 (4): 705–19. doi:10.1006/jmcc.1998.0903. PMID 10329199.
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Knuefermann P, Chen P, Misra A, et al. (2002). "Myotrophin/V-1, a protein up-regulated in the failing human heart and in postnatal cerebellum, converts NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers". J. Biol. Chem. 277 (26): 23888–97. doi:10.1074/jbc.M202937200. PMID 11971907.
Gupta S, Sen S (2002). "Myotrophin-kappaB DNA interaction in the initiation process of cardiac hypertrophy". Biochim. Biophys. Acta. 1589 (3): 247–60. doi:10.1016/S0167-4889(02)00178-7. PMID 12031792.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Xiong Z, Liu E, Yan Y, et al. (2006). "An unconventional antigen translated by a novel internal ribosome entry site elicits antitumor humoral immune reactions". J. Immunol. 177 (7): 4907–16. doi:10.4049/jimmunol.177.7.4907. PMC 3902139. PMID 16982933.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

v t e PDB gallery
1myo: SOLUTION STRUCTURE OF MYOTROPHIN, NMR, 44 STRUCTURES 2myo: SOLUTION STRUCTURE OF MYOTROPHIN, NMR, MINIMIZED AVERAGE STRUCTURE

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