Exosome RNA helicase MTR4

MTREX
Identifiers
Aliases	MTREX, Dob1, KIAA0052, Mtr4, fSAP118, Ski2 like RNA helicase 2, Mtr4 exosome RNA helicase, SKIV2L2
External IDs	OMIM: 618122; MGI: 1919448; GeneCards: MTREX
Enzyme activity
Gene location (Human)
Chr.	Chromosome 5 (human)
End	55,425,579 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	113,063,932 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; gonad; ; epithelium of colon; ; ventricular zone; ; testicle; ; ganglionic eminence; ; jejunal mucosa; ; Skeletal muscle tissue of rectus abdominis; ; islet of Langerhans;
	Top expressed in
	primitive streak; ; genital tubercle; ; masseter muscle; ; ureter; ; otic vesicle; ; tail of embryo; ; Paneth cell; ; otic placode; ; facial motor nucleus; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA helicase activity; nucleotide binding; protein binding; ATP binding; hydrolase activity; helicase activity; nucleic acid binding; RNA binding;
Cellular component	catalytic step 2 spliceosome; spliceosomal complex; nucleolus; exosome (RNase complex); nucleus; nucleoplasm; nuclear exosome (RNase complex); TRAMP complex;
Biological process	mRNA processing; maturation of 5.8S rRNA; RNA splicing; rRNA processing; mRNA splicing, via spliceosome; RNA catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	23517
	72198
	ENSG00000039123
	ENSMUSG00000016018
	P42285
	Q9CZU3
	NM_015360
	NM_028151
	NP_056175
	NP_082427
	Wikidata
View/Edit Human	View/Edit Mouse

Exosome RNA helicase MTR4 is an enzyme that in humans is encoded by the MTREX gene (previously SKIV2L2). As an RNA helicase, the protein MTR4 participates in unwinding RNA, and is part of multiple protein complex, including TRAMP-like, NEXT, and PAXT. MTR4 is inhibited by NRDE2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000039123 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016018 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".
1 2 "Exosome RNA helicase MTR4". uniprot.org. UniProt consortium. Retrieved 2026-08-01.

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Brouwer R, Allmang C, Raijmakers R, et al. (2001). "Three novel components of the human exosome". J. Biol. Chem. 276 (9): 6177–84. doi:10.1074/jbc.M007603200. hdl:2066/186951. PMID 11110791.
Chen CY, Gherzi R, Ong SE, et al. (2002). "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs". Cell. 107 (4): 451–64. doi:10.1016/S0092-8674(01)00578-5. PMID 11719186. S2CID 14817671.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
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Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
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Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.
Nagahama M, Yamazoe T, Hara Y, et al. (2006). "The AAA-ATPase NVL2 is a component of pre-ribosomal particles that interacts with the DExD/H-box RNA helicase DOB1". Biochem. Biophys. Res. Commun. 346 (3): 1075–82. doi:10.1016/j.bbrc.2006.06.017. PMID 16782053.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Schilders G, van Dijk E, Pruijn GJ (2007). "C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing". Nucleic Acids Res. 35 (8): 2564–72. doi:10.1093/nar/gkm082. PMC 1885644. PMID 17412707.
Yang CT, Hindes AE, Hultman KA, Johnson SL (2007). "Mutations in gfpt1 and skiv2l2 cause distinct stage-specific defects in larval melanocyte regeneration in zebrafish". PLOS Genet. 3 (6): e88. doi:10.1371/journal.pgen.0030088. PMC 1885281. PMID 17542649.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000039123 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000016018 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)".

[uniprot-6] 1 2 "Exosome RNA helicase MTR4". uniprot.org. UniProt consortium. Retrieved 2026-08-01.

Exosome RNA helicase MTR4

References

Further reading