MX1

MX1
Identifiers
Aliases	MX1, IFI-78K, IFI78, MX, MxA, MX dynamin like GTPase 1, lncMX1-215
External IDs	OMIM: 147150; MGI: 97244; GeneCards: MX1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3LJB, 3SZR, 3ZYS, 4P4S, 4P4T, 4P4U
Gene location (Human)
Chr.	Chromosome 21 (human)
End	41,470,071 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	97,362,100 bp
RNA expression pattern
	Top expressed in
	trigeminal ganglion; ; spinal ganglia; ; nasal epithelium; ; palpebral conjunctiva; ; monocyte; ; decidua; ; olfactory zone of nasal mucosa; ; granulocyte; ; spleen; ; human penis;
	Top expressed in
	embryo; ; surface ectoderm; ; duodenum; ; thymus; ; choroid plexus of fourth ventricle; ; yolk sac; ; muscle of thigh; ; liver; ; islet of Langerhans; ; perirhinal cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity; microtubule binding; identical protein binding;
Cellular component	cytoplasm; cytosol; nuclear membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; perinuclear region of cytoplasm; nucleus; mitochondrial membranes;
Biological process	defense response; immune system process; response to virus; type I interferon signaling pathway; innate immune response; signal transduction; apoptotic process; response to type I interferon; negative regulation of viral genome replication; mitochondrial fission; dynamin family protein polymerization involved in mitochondrial fission; membrane fusion; defense response to virus;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	4599
	17858
	ENSG00000157601
	ENSMUSG00000023341
	P20591
	Q9WVP9
	NM_001144925; NM_001178046; NM_001282920; NM_002462
	NM_013606
	NP_001138397; NP_001171517; NP_001269849; NP_002453
	NP_038634
	Wikidata
View/Edit Human	View/Edit Mouse

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.

In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Furthermore, the human orthologue MxA is a major host determinant for influenza viruses of animal origin. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000157601 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023341 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–818. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.
1 2 "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".
↑ Ciminski K, Chase G, Beer M, Schwemmle M (Feb 2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.

Pavlovic J, Haller O, Staeheli P (Apr 1992). "Human and mouse Mx proteins inhibit different steps of the influenza virus multiplication cycle". Journal of Virology. 66 (4): 2564–2569. doi:10.1128/JVI.66.4.2564-2569.1992. PMC 289059. PMID 1548781.
Horisberger MA (Aug 1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology. 66 (8): 4705–4709. doi:10.1128/JVI.66.8.4705-4709.1992. PMC 241296. PMID 1629950.
Petersen MB, Slaugenhaupt SA, Lewis JG, Warren AC, Chakravarti A, Antonarakis SE (Mar 1991). "A genetic linkage map of 27 markers on human chromosome 21". Genomics. 9 (3): 407–419. doi:10.1016/0888-7543(91)90406-5. PMID 1674496.
Horisberger MA, McMaster GK, Zeller H, Wathelet MG, Dellis J, Content J (Mar 1990). "Cloning and sequence analyses of cDNAs for interferon- and virus-induced human Mx proteins reveal that they contain putative guanine nucleotide-binding sites: functional study of the corresponding gene promoter". Journal of Virology. 64 (3): 1171–1181. doi:10.1128/JVI.64.3.1171-1181.1990. PMC 249231. PMID 2154602.
Pavlovic J, Zürcher T, Haller O, Staeheli P (Jul 1990). "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". Journal of Virology. 64 (7): 3370–3375. doi:10.1128/JVI.64.7.3370-3375.1990. PMC 249583. PMID 2161946.
Aebi M, Fäh J, Hurt N, et al. (Nov 1989). "cDNA structures and regulation of two interferon-induced human Mx proteins". Molecular and Cellular Biology. 9 (11): 5062–5072. doi:10.1128/mcb.9.11.5062. PMC 363658. PMID 2481229.
Weitz G, Bekisz J, Zoon K, Arnheiter H (Dec 1989). "Purification and characterization of a human Mx protein". Journal of Interferon Research. 9 (6): 679–689. doi:10.1089/jir.1989.9.679. PMID 2607176.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Melen K, Keskinen P, Ronni T, Sareneva T, Lounatmaa K, Julkunen I (Sep 1996). "Human MxB protein, an interferon-alpha-inducible GTPase, contains a nuclear targeting signal and is localized in the heterochromatin region beneath the nuclear envelope". Journal of Biological Chemistry. 271 (38): 23478–23486. doi:10.1074/jbc.271.38.23478. PMID 8798556.
Ponten A, Sick C, Weeber M, Haller O, Kochs G (Apr 1997). "Dominant-negative mutants of human MxA protein: domains in the carboxy-terminal moiety are important for oligomerization and antiviral activity". Journal of Virology. 71 (4): 2591–2599. doi:10.1128/JVI.71.4.2591-2599.1997. PMC 191379. PMID 9060610.
Fernández M, Quiroga JA, Martín J, et al. (Apr 1997). "Impaired interferon induction of human MxA protein in chronic hepatitis B virus infection". Journal of Medical Virology. 51 (4): 332–337. doi:10.1002/(SICI)1096-9071(199704)51:4<332::AID-JMV12>3.0.CO;2-K. PMID 9093949. S2CID 12578068.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li Y, Youssoufian H (Dec 1997). "MxA overexpression reveals a common genetic link in four Fanconi anemia complementation groups". The Journal of Clinical Investigation. 100 (11): 2873–2880. doi:10.1172/JCI119836. PMC 508494. PMID 9389754.
Kochs G, Trost M, Janzen C, Haller O (Jul 1998). "MxA GTPase: oligomerization and GTP-dependent interaction with viral RNP target structures". Methods. 15 (3). San Diego, Calif.: 255–263. doi:10.1006/meth.1998.0629. PMID 9735310.
Weber F, Haller O, Kochs G (Jan 2000). "MxA GTPase blocks reporter gene expression of reconstituted Thogoto virus ribonucleoprotein complexes". Journal of Virology. 74 (1): 560–563. doi:10.1128/JVI.74.1.560-563.2000. PMC 111572. PMID 10590150.
Hijikata M, Ohta Y, Mishiro S (2000). "Identification of a single nucleotide polymorphism in the MxA gene promoter (G/T at nt -88) correlated with the response of hepatitis C patients to interferon". Intervirology. 43 (2): 124–127. doi:10.1159/000025035. PMID 10971132. S2CID 19445539.
Engelhardt OG, Ullrich E, Kochs G, Haller O (Dec 2001). "Interferon-induced antiviral Mx1 GTPase is associated with components of the SUMO-1 system and promyelocytic leukemia protein nuclear bodies". Experimental Cell Research. 271 (2): 286–295. doi:10.1006/excr.2001.5380. PMID 11716541.
Hijikata M, Mishiro S, Miyamoto C, Furuichi Y, Hashimoto M, Ohta Y (2002). "Genetic polymorphism of the MxA gene promoter and interferon responsiveness of hepatitis C patients: revisited by analyzing two SNP sites (-123 and -88) in vivo and in vitro". Intervirology. 44 (6): 379–382. doi:10.1159/000050075. PMID 11805446. S2CID 46752867.
Kochs G, Haener M, Aebi U, Haller O (Apr 2002). "Self-assembly of human MxA GTPase into highly ordered dynamin-like oligomers". Journal of Biological Chemistry. 277 (16): 14172–14176. doi:10.1074/jbc.M200244200. PMID 11847228.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000157601 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023341 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Haller_2007-5] Haller O, Staeheli P, Kochs G (Jul 2007). "Interferon-induced Mx proteins in antiviral host defense". Biochimie. 89 (6–7): 812–818. doi:10.1016/j.biochi.2007.04.015. PMID 17570575.

[entrez-6] 1 2 "Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)".

[7] Ciminski K, Chase G, Beer M, Schwemmle M (Feb 2021). "Influenza A Viruses: Understanding Human Host Determinants". Trends in Molecular Medicine. 27 (2): 104–112. doi:10.1016/j.molmed.2020.09.014. PMID 33097424. S2CID 225058479.

MX1

References

Further reading