Myosin regulatory light chain 11

MYL11
Identifiers
Aliases	MYL11, MYLPF, myosin light chain 11, HUMMLC2B, MLC2B, myosin light chain, phosphorylatable, fast skeletal muscle, MRLC2, DA1C
External IDs	OMIM: 617378; MGI: 97273; GeneCards: MYL11
Gene location (Human)
Chr.	Chromosome 16 (human)
End	30,377,991 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	126,813,470 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; muscle of thigh; ; gastrocnemius muscle; ; vastus lateralis muscle; ; glutes; ; thoracic diaphragm; ; body of tongue;
	Top expressed in
	temporal muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; digastric muscle; ; medial head of gastrocnemius muscle; ; muscle of thigh; ; vastus lateralis muscle; ; body of femur; ; intercostal muscle; ; ankle;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; structural constituent of muscle; metal ion binding;
Cellular component	lysosomal membrane; cytosol; muscle myosin complex; myosin complex;
Biological process	muscle contraction; skeletal muscle tissue development; immune response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	29895
	17907
	ENSG00000180209
	ENSMUSG00000030672
	Q96A32
	P97457
	NM_013292; NM_001324458; NM_001324459
	NM_016754; NM_001347655
	NP_001311387; NP_001311388; NP_037424
	NP_001334584; NP_058034
	Wikidata
View/Edit Human	View/Edit Mouse

Myosin regulatory light chain 11 is a protein that in humans is encoded by the MYL11 gene (previously MYLPF). Based on research on an ortholog in zebrafish, this protein is predicted to be a regulatory subunit for myosin which is involved in early muscle development, and to also be involved in muscle contraction.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000180209 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030672 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Myosin light chain, phosphorylatable, fast skeletal muscle".
↑ "Myosin regulatory light chain 11". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

Nudel U, Calvo JM, Shani M, Levy Z (Sep 1984). "The nucleotide sequence of a rat myosin light chain 2 gene". Nucleic Acids Research. 12 (18): 7175–86. doi:10.1093/nar/12.18.7175. PMC 320149. PMID 6091059.
Garfinkel LI, Periasamy M, Nadal-Ginard B (Sep 1982). "Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin". The Journal of Biological Chemistry. 257 (18): 11078–86. doi:10.1016/S0021-9258(18)33935-8. PMID 6179945.
Sachdev S, Raychowdhury MK, Sarkar S (Oct 2003). "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships". DNA Sequence. 14 (5): 339–50. doi:10.1080/1042517031000154952. PMID 14756420. S2CID 7284166.
Amoresano A, Di Costanzo A, Leo G, Di Cunto F, La Mantia G, Guerrini L, Calabrò V (Apr 2010). "Identification of DeltaNp63alpha protein interactions by mass spectrometry". Journal of Proteome Research. 9 (4): 2042–8. doi:10.1021/pr9011156. PMID 20085233.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000180209 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030672 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Myosin light chain, phosphorylatable, fast skeletal muscle".

[6] "Myosin regulatory light chain 11". uniprot.org. UniProt consortium. Retrieved 2026-09-12.

Myosin regulatory light chain 11

References

Further reading