MYOZ1

MYOZ1

Identifiers

MYOZ1, CS-2, FATZ, MYOZ, myozenin 1

External IDs

OMIM: 605603; MGI: 1929471; GeneCards: MYOZ1

Gene location (Human)

Chr.	Chromosome 10 (human)

Band	10q22.2	Start	73,631,612 bp
Band	10q22.2	End	73,641,474 bp

Gene location (Mouse)

Chr.	Chromosome 14 (mouse)

Band	14\|14 A3	Start	20,699,175 bp
Band	14\|14 A3	End	20,706,608 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

muscle of thigh

Skeletal muscle tissue of rectus abdominis

gastrocnemius muscle

biceps brachii

vastus lateralis muscle

Skeletal muscle tissue of biceps brachii

triceps brachii muscle

glutes

thoracic diaphragm

deltoid muscle

Top expressed in

temporal muscle

triceps brachii muscle

muscle of thigh

sternocleidomastoid muscle

medial head of gastrocnemius muscle

digastric muscle

ankle

quadriceps femoris muscle

tibialis anterior muscle

extensor digitorum longus muscle

More reference expression data


More reference expression data

Gene ontology
Molecular function	FATZ binding protein binding actin binding telethonin binding protein serine/threonine phosphatase inhibitor activity
Cellular component	cell projection nucleus pseudopodium actin cytoskeleton Z discdkac
Biological process	myofibril assembly negative regulation of transcription by RNA polymerase II skeletal muscle tissue development negative regulation of phosphoprotein phosphatase activity negative regulation of skeletal muscle tissue regeneration skeletal muscle fiber adaptation sarcomere organization negative regulation of calcineurin-NFAT signaling cascade
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


58529


59011


ENSG00000177791


ENSMUSG00000068697


Q9NP98


Q9JK37

RefSeq (mRNA)


NM_021245


NM_021508

RefSeq (protein)


NP_067068


NP_067483

Location (UCSC)

Chr 10: 73.63 – 73.64 Mb

Chr 14: 20.7 – 20.71 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Myozenin-1 is a protein that in humans is encoded by the MYOZ1 gene.

Interactions

MYOZ1 has been shown to interact with Telethonin, FLNC and Actinin, alpha 2.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000177791 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068697 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Takada F, Vander Woude DL, Tong HQ, Thompson TG, Watkins SC, Kunkel LM, Beggs AH (Feb 2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proc Natl Acad Sci USA. 98 (4): 1595–600. doi:10.1073/pnas.041609698. PMC 29302. PMID 11171996.
1 2 3 4 Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic' S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G (Jan 2001). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J Biol Chem. 275 (52): 41234–42. doi:10.1074/jbc.M007493200. hdl:11368/1698365. PMID 10984498.
↑ "Entrez Gene: MYOZ1 myozenin 1".
1 2 Frey, Norbert; Olson Eric N (Apr 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. ISSN 0021-9258. PMID 11842093.

Further reading

Faulkner G, Pallavicini A, Formentin E, et al. (1999). "ZASP: a new Z-band alternatively spliced PDZ-motif protein". J. Cell Biol. 146 (2): 465–75. doi:10.1083/jcb.146.2.465. PMC 3206570. PMID 10427098.
Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi:10.1073/pnas.260501097. PMC 18970. PMID 11114196.
Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi:10.1074/jbc.M200712200. PMID 11842093.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Gontier Y, Taivainen A, Fontao L, et al. (2006). "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins". J. Cell Sci. 118 (Pt 16): 3739–49. doi:10.1242/jcs.02484. PMID 16076904.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Arola AM, Sanchez X, Murphy RT, et al. (2007). "Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy". Mol. Genet. Metab. 90 (4): 435–40. doi:10.1016/j.ymgme.2006.12.008. PMID 17254821.
Posch MG, Perrot A, Dietz R, et al. (2007). "Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy" (PDF). Mol. Genet. Metab. 91 (2): 207–8. doi:10.1016/j.ymgme.2007.02.014. PMID 17434779.

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