MZB1

MZB1
Identifiers
Aliases	MZB1, MEDA-7, PACAP, pERp1, marginal zone B and B1 cell specific protein
External IDs	OMIM: 609447; MGI: 1917066; GeneCards: MZB1
Gene location (Human)
Chr.	Chromosome 5 (human)
End	139,390,081 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	35,782,420 bp
RNA expression pattern
	Top expressed in
	thymus; ; spleen; ; lymph node; ; appendix; ; rectum; ; mucosa of transverse colon; ; tonsil; ; bone marrow cell; ; trachea; ; duodenum;
	Top expressed in
	spleen; ; ileum; ; jejunum; ; bone marrow; ; colon; ; thymus; ; duodenum; ; granulocyte; ; embryo; ; pharynx;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; extracellular region; endoplasmic reticulum lumen; endoplasmic reticulum; endoplasmic reticulum chaperone complex;
Biological process	integrin activation; regulation of cell population proliferation; positive regulation of cell population proliferation; apoptotic process; regulation of B cell proliferation; regulation of insulin receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51237
	69816
	ENSG00000170476
	ENSMUSG00000024353
	Q8WU39
	Q9D8I1
	NM_016459
	NM_027222
	NP_057543
	NP_081498
	Wikidata
View/Edit Human	View/Edit Mouse

Marginal zone B and B1 cell-specific protein is a protein that in humans is encoded by the MZB1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170476 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024353 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Marginal zone B and B1 cell-specific protein".

Zhang H, Chen S, Huang L (May 2012). "[Proteomics-based identification of proapoptotic caspase adapter protein as a novel serum marker of non-small cell lung cancer]". Zhongguo Fei AI Za Zhi = Chinese Journal of Lung Cancer. 15 (5): 287–93. doi:10.3779/j.issn.1009-3419.2012.05.07. PMC 6000130. PMID 22613335.
Vaudry D, Rousselle C, Basille M, Falluel-Morel A, Pamantung TF, Fontaine M, Fournier A, Vaudry H, Gonzalez BJ (April 2002). "Pituitary adenylate cyclase-activating polypeptide protects rat cerebellar granule neurons against ethanol-induced apoptotic cell death". Proceedings of the National Academy of Sciences of the United States of America. 99 (9): 6398–403. Bibcode:2002PNAS...99.6398V. doi:10.1073/pnas.082112699. PMC 122960. PMID 11972030.
Bonfoco E, Li E, Kolbinger F, Cooper NR (August 2001). "Characterization of a novel proapoptotic caspase-2- and caspase-9-binding protein". The Journal of Biological Chemistry. 276 (31): 29242–50. doi:10.1074/jbc.M100684200. PMID 11350957.
Katoh M, Katoh M (July 2003). "MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, encodes secreted-type protein with conserved cysteine residues". International Journal of Oncology. 23 (1): 235–41. PMID 12792799.
Zhang H, Chen X, Sairam MR (September 2011). "Novel hormone-regulated genes in visceral adipose tissue: cloning and identification of proinflammatory cytokine-like mouse and human MEDA-7: implications for obesity, insulin resistance and the metabolic syndrome". Diabetologia. 54 (9): 2368–80. doi:10.1007/s00125-011-2212-7. PMID 21688198.
Flach H, Rosenbaum M, Duchniewicz M, Kim S, Zhang SL, Cahalan MD, Mittler G, Grosschedl R (November 2010). "Mzb1 protein regulates calcium homeostasis, antibody secretion, and integrin activation in innate-like B cells". Immunity. 33 (5): 723–35. doi:10.1016/j.immuni.2010.11.013. PMC 3125521. PMID 21093319.
Shimizu Y, Meunier L, Hendershot LM (October 2009). "pERp1 is significantly up-regulated during plasma cell differentiation and contributes to the oxidative folding of immunoglobulin". Proceedings of the National Academy of Sciences of the United States of America. 106 (40): 17013–8. Bibcode:2009PNAS..10617013S. doi:10.1073/pnas.0811591106. PMC 2761359. PMID 19805157.
van Anken E, Pena F, Hafkemeijer N, Christis C, Romijn EP, Grauschopf U, Oorschot VM, Pertel T, Engels S, Ora A, Lástun V, Glockshuber R, Klumperman J, Heck AJ, Luban J, Braakman I (October 2009). "Efficient IgM assembly and secretion require the plasma cell induced endoplasmic reticulum protein pERp1". Proceedings of the National Academy of Sciences of the United States of America. 106 (40): 17019–24. Bibcode:2009PNAS..10617019V. doi:10.1073/pnas.0903036106. PMC 2761347. PMID 19805154.
Matsumura S, Imoto I, Kozaki K, Matsui T, Muramatsu T, Furuta M, Tanaka S, Sakamoto M, Arii S, Inazawa J (July 2012). "Integrative array-based approach identifies MZB1 as a frequently methylated putative tumor suppressor in hepatocellular carcinoma". Clinical Cancer Research. 18 (13): 3541–51. doi:10.1158/1078-0432.CCR-11-1007. PMID 22573353.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170476 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024353 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Marginal zone B and B1 cell-specific protein".

MZB1

References

Further reading