Manjula Reddy earned her PhD from the Centre for Cellular and Molecular Biology in 2002. She started her own lab at the institution in 2007.
Research
Manjula Reddy conducts research on bacterial cell walls.
She identified a novel "spacemaker" enzyme encoded by the open reading frame called MepK in Escherichia coli. She found that this enzyme hydrolyses certain cross-links in peptidoglycan thereby allowing the bacterial cell wall to expand. She aims to develop novel antimicrobials that can target the peptidoglycan synthesis pathway. She uses the model organisms Mycobacterium smegmatis and Escherichia coli.
She was part of the team of scientists who patented the process for identifying mutagens and anti-mutagens. This process was patented from 1999 to 2018 in the United States. The other scientists in the team were Jayaraman Gowrishankar and Shanti M. Bharatan.
She has stated in an interview that her father, Mohan Reddy, and her mother were supportive of her career as a scientist. She is married to a cardiologist and has two sons.
Chodisetti, Pavan Kumar, and Manjula Reddy. "Peptidoglycan hydrolase of an unusual cross-link cleavage specificity contributes to bacterial cell wall synthesis." Proceedings of the National Academy of Sciences 116.16 (2019): 7825-7830.
Singh, Santosh Kumar, et al. "Regulated proteolysis of a cross-link–specific peptidoglycan hydrolase contributes to bacterial morphogenesis." Proceedings of the National Academy of Sciences 112.35 (2015): 10956-10961.
Reddy, Manjula. "Role of FtsEX in cell division of Escherichia coli: viability of ftsEX mutants is dependent on functional SufI or high osmotic strength." Journal of bacteriology 189.1 (2007): 98-108.
