SLC61A1

SLC61A1
Identifiers
Aliases	SLC61A1, hsMOT2, major facilitator superfamily domain containing 5, MFSD5, Solute carrier family 61 member 1
External IDs	MGI: 2145901; GeneCards: SLC61A1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,254,406 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,190,189 bp
RNA expression pattern
	Top expressed in
	skin of leg; ; skin of abdomen; ; mucosa of transverse colon; ; right adrenal cortex; ; granulocyte; ; left adrenal gland; ; left adrenal cortex; ; gums; ; gingival epithelium; ; apex of heart;
	Top expressed in
	lip; ; stroma of bone marrow; ; transitional epithelium of urinary bladder; ; esophagus; ; right kidney; ; skin of external ear; ; calvaria; ; yolk sac; ; choroid plexus of fourth ventricle; ; granulocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; molybdate ion transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	molybdate ion transport; ion transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84975
	106073
	ENSG00000182544
	ENSMUSG00000045665
	Q6N075
	Q921Y4
	NM_001170790; NM_032889
	NM_134100
	NP_001164261; NP_116278
	NP_598861
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier family 61 member 1 is a protein that in humans is encoded by the SLC61A1 gene (previously MFSD4). This protein is responsible for molybdenum uptake instead of the cell. It has previously been described as an atypical SLC, and it is expressed in neuronal plasma membrane. It is a plausible Solute carrier transporter. It transports molybdate anions, and it interacts with GLP-1R. In humans, it is encoded by the gene SLC61A1.

SLC61A1/MFSD5 belongs to AMTF6.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Solute carrier family 61 member 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.
↑ Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.
↑ Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.
↑ Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.
↑ Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.
↑ "genecards.org".
↑ Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182544 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045665 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-5] 1 2 "Solute carrier family 61 member 1". uniprot.org. UniProt consortium. Retrieved 2026-09-13.

[6] Perland E, Lekholm E, Eriksson MM, Bagchi S, Arapi V, Fredriksson R (2016). "The Putative SLC Transporters Mfsd5 and Mfsd11 Are Abundantly Expressed in the Mouse Brain and Have a Potential Role in Energy Homeostasis". PLOS ONE. 11 (6) e0156912. Bibcode:2016PLoSO..1156912P. doi:10.1371/journal.pone.0156912. PMC 4896477. PMID 27272503.

[7] Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID 27939446.

[8] Tejada-Jiménez M, Galván A, Fernández E (April 2011). "Algae and humans share a molybdate transporter". Proceedings of the National Academy of Sciences of the United States of America. 108 (16): 6420–6425. Bibcode:2011PNAS..108.6420T. doi:10.1073/pnas.1100700108. PMC 3080982. PMID 21464289.

[9] Huang X, Dai FF, Gaisano G, Giglou K, Han J, Zhang M, et al. (September 2013). "The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity". Molecular Endocrinology. 27 (9): 1550–1563. doi:10.1210/me.2013-1047. PMC 5415235. PMID 23864651.

[10] "genecards.org".

[11] Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC 5627054. PMID 28878041.