Mihai Netea

Mihai Netea
Mihai Netea in 2016
Born1968 (age 57–58)
Cluj, Romania
EducationRadboud University Nijmegen
Occupationsphysician, professor

Mihai Gheorghe Netea (born 1968, Cluj, Romania) is a Romanian-Dutch physician and professor at Radboud University Nijmegen, specialized in infectious disease, immunology, and global health.

Netea studied medicine at the Medico-Pharmaceutical Institute in Cluj-Napoca. He received a doctoral degree in 1998 at Radboud University, with a dissertation on the role of cytokines in sepsis, written under the direction of Jos van der Meer.

He joined the University of Colorado Denver as a postdoctoral researcher and then returned to conclude his clinical training as an infectious diseases specialist. Since 2008 he heads the division of Experimental Medicine, Department of Internal Medicine, Nijmegen University Nijmegen Medical Center.

Netea's field of study includes the innate immune system and its capacity to "memorize" infections, as well as its recognition of Fungi pathogens. He examined system's response to Candida albicans, a sepsis trigger. Additionally, he tried to search for genetic diseases that can make individuals more vulnerable to this type of infections.

Netea co-published more than 900 scientific papers in journals such as The New England Journal of Medicine, Nature, Science, and PNAS.

For his academic work, Netea received several grants: a Vidi grant in 2005, a Vici grant in 2010, and European Research Council Consolidator Grant in 2012. In 2016, he was awarded the Spinoza Prize. He is a member of Academia Europaea since 2015 and of the Royal Netherlands Academy of Arts and Sciences since 2016.

Netea is known for his breakthrough in the area of Trained immunity. Netea's research attempts to translate information obtained through the assessment of human genetic variation in patients into novel diagnostic and therapeutic approaches.

Areas of research

Associated institutions

Positions held

Prizes and awards

Publications

Peer-reviewed (selection)

  • M.G. Netea (1998). Modulation of proinflammatory cytokines (Thesis). Radboud University Nijmegen. 419 pp. hdl:2066/146584. ISBN 90-90-11693-1.
  • Bekkering S, Arts RJW, ... , Stunnenberg H, Riksen NP, Netea MG. Metabolic Induction of Trained Immunity through the Mevalonate Pathway. Cell. 2018; 172: pages 135-146 (impact fact0r 28.7)
  • Mitroulis I, Ruppova K, Wang B, ... , Hajishengallis G, Netea MG, Chavakis T. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018; 172: pages 147-161 (28.7).
  • Arts RJW, Moorlag SJCFM, Novakovic B, ... , Stunnenberg HG, van Crevel R, Netea MG. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe 2018; 23: paages 89-100 (13.4)
  • Ter Horst R, Jaeger M, Smeekens SP, ... , Wijmenga C, Notebaart RA, Joosten LA, Netea MG. Host and Environmental Factors Influencing Individual Human Cytokine Responses. Cell. 2016;167: pages 1111-1124 (28.7)
  • Li Y, Oosting M, Smeekens SP, Jaeger M, ... , Wijmenga C, Kumar V, Netea MG. A Functional Genomics Approach to Understand Variation in Cytokine Production in Humans. Cell. 2016;167: pages 1099-1110 (28.7)
  • Schirmer M, Smeekens SP, Vlamakis H, ... , Wijmenga C, Netea MG, Xavier RJ. Linking the Human Gut Microbiome to Inflammatory Cytokine Production Capacity. Cell. 2016;167: pages 1125-1136 (28.7)
  • Netea MG, Joosten LA, Latz E, Mills KH, Natoli G, Stunnenberg HG, O'Neill LA, Xavier RJ. Trained immunity: A program of innate immune memory in health and disease. Science. 2016 April 22;352(6284):aaf1098 (31.4)
  • Cheng SC, Brendon S, ... , van der Poll, Netea MG. Broad defects in energy metabolism of leukocytes underlie immunoparalysis in sepsis. Nature Immunology, 2016, 17: pages 406-413 (21.7)
  • Cheng SC, Quintin J, Cramer RA, ... , Stunnenberg HG, Xavier RJ, Netea MG. mTOR/HIF1a-mediated aerobic glycolysis as metabolic basis for trained immunity. Science, 2014, 345: page 1250684 (31.4)
  • Saeed S, Quintin J, Kerstens HHD, ... , Xavier RJ, Logie C, Netea MG, Stunnenberg HG. Epigenetic programming during monocyte to macrophage differentiation and trained innate immunity. Science, 2014, 345: page 1251086 (31.4)
  • Li Y, Oosting M, Deelen P, Ricaño-Ponce I, Smeekens S, Jaeger M, Matzaraki V, Swertz MA, Xavier RJ, Franke L, Wijmenga C, Joosten LA, Kumar V, Netea MG. Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi. Nature Medicine. 2016 July 4. doi: 10.1038/nm.4139 (30)
  • Kumar V, Cheng SC, Johnson MD, ... , Xavier RJ, Kullberg BJ, Wijmenga C, Netea MG. Immunochip SNP array identifies novel genetic variants conferring susceptibility to candidemia. Nature Communications, 2014, 5: page 4675 (10.7)
  • Laayouni H, Oosting M, Luisi P, ... , Joosten LAB, Bertranpetit J, Netea MG. Convergent evolution in European and Rroma populations: pressure exerted by plague on Toll-like receptors. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111: pages 2668-73 (9.8)
  • Lionakis M, Swamydas M, Fischer B, ..., Gao JL, Kullberg BJ, Netea MG, Murphy PM. Chemokine Receptor CX3CR1 Modulates Susceptibility to Systemic Candidiasis in Mice and Humans. Journal of Clinical Investigation 2013; 123(12): pages 5035-51 (13.9)
  • Smeekens SP, Ng A, ... van der Meer JW, Wijmenga C, Netea MG, Xavier RJ. Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans. Nature Communications 2013;4: page 1342 (10.0)
  • Kleinnijenhuis J, Quintin J, Preijers F, Joosten L.A.B., Ifrim DC, Saeed S, Jacobs C, van Loenhout J, de Jong D, Stunnenberg HG, Xavier RJ, van der Meer JWM, van Crevel R, Netea MG. BCG induces NOD2-dependent non-specific protection to reinfection via epigenetic reprogramming of monocytes. Proceedings of the National Academy of Sciences of the United States of America 2012, pages 17537-42 (9.4) 17. van de Veerdonk FL, Plantinga TS, Hoischen A, Smeekens SP, Joosten LA, Gilissen C, Arts P, Rosentul DC, Carmichael AJ, Smits-van der Graaf CA, Kullberg BJ, van der Meer JW, Lilic D, Veltman JA, Netea MG. STAT1 mutations in autosomal dominant chronic mucocutaneous candidiasis. The New England Journal of Medicine 2011 July 7;365(1): pages 54-61 (47)
  • Netea MG, Quintin J, van der Meer JW. Trained immunity: a memory for innate host defense. Cell Host Microbe.19;9: pages 355-61. (13.4).
  • Bart Ferwerda, Gerben Ferwerda, Theo S. Plantinga, ... , Bart-Jan Kulberg, Gordon D. Brown, Netea MG. Human dectin-1 deficiency and mucocutaneous fungal infections The New England Journal of Medicine, 2009, 361;1760-7 (47)
  • Netea MG, Gow NA, Munro CA, ... , Van der Meer JW, Brown AJ, Kullberg BJ. Immune sensing of Candida albicans requires cooperative recognition of mannans and glucans by lectin and Toll-like receptors. Journal of Clinical Investigation 2006 June;116(6): pages 1642-50. (15.7)
  • Netea, M. (2022). O istorie genetică (incompletă) a românilor [An (incomplete) genetic history of the Romanians] (in Romanian). Humanitas, Bucharest.

Science-fiction

  • Netea, M.G. (2015). North-West Passage to the Moon. CreateSpace Independent Publishing Platform, ISBN 1515367398

Research grants

Patents

References

  1. 1 2 "FELICITĂRI! Mihai Netea, un cercetător din Cluj, primeşte "Nobelul Olandei". Este considerat un pionier în domeniu". clujcapitala.ro (in Romanian). June 13, 2016. Retrieved April 16, 2020.
  2. 1 2 3 4 5 "Mihai Netea: A new idea in immunology". Radboud University Nijmegen. Archived from the original on April 14, 2020. Retrieved April 14, 2020.
  3. 1 2 "Prof. Mihai G. Netea MD PhD". ISCOMS. Archived from the original on January 20, 2017. Retrieved April 14, 2020.
  4. ↑ "Prof.dr. M.G. (Mihai) Netea. Publications". NARCIS. Retrieved April 14, 2020.
  5. 1 2 "Mihai Netea. Personal prizes & awards (national & international)". Radboud University Nijmegen. Archived from the original on April 14, 2020. Retrieved April 14, 2020.
  6. ↑ "NWO Spinoza prize 2016". Netherlands Organisation for Scientific Research. Archived from the original on 11 April 2020.
  7. ↑ "Mihae Netea". Academia Europaea. Archived from the original on 28 March 2019.
  8. ↑ "Mihai Netea". Royal Netherlands Academy of Arts and Sciences. Archived from the original on 18 April 2020.
  9. ↑ Netea, Mihai G.; Joosten, Leo A. B.; Latz, Eicke; Mills, Kingston H. G.; Natoli, Gioacchino; Stunnenberg, Hendrik G.; O'Neill, Luke A. J.; Xavier, Ramnik J. (22 April 2016). "Trained immunity: A program of innate immune memory in health and disease". Science. 352 (6284) aaf1098. doi:10.1126/science.aaf1098. PMC 5087274. PMID 27102489.[non-primary source needed]
  10. ↑ Netea, Mihai G. (August 2013). "Training innate immunity: the changing concept of immunological memory in innate host defence". European Journal of Clinical Investigation. 43 (8): 881–884. doi:10.1111/eci.12132. PMID 23869409.[non-primary source needed]
  11. ↑ Netea, M. G.; Joosten, L. A.; Latz, E.; Mills, K. H.; Natoli, G.; Stunnenberg, H. G.; O'Neill, L. A.; Xavier, R. J. (2016). "Trained immunity: a program of innate immune memory in health and disease". Science. 352 (6284) aaf1098. doi:10.1126/science.aaf1098. PMC 5087274. PMID 27102489.[non-primary source needed]
  12. ↑ Netea, Mihai; Ferwerda, Gerben; Van Der Graaf, Chantal; Van Der Meer, Jos W.; Kullberg, Bart Jan (November 2006). "Recognition of Fungal Pathogens by Toll-Like Receptors". Current Pharmaceutical Design. 12 (32): 4195–4201. doi:10.2174/138161206778743538. PMID 17100622.[non-primary source needed]
  13. ↑ Kumar, Vinod; van de Veerdonk, Frank L.; Netea, Mihai G. (December 2018). "Antifungal immune responses: emerging host–pathogen interactions and translational implications". Genome Medicine. 10 (1) 39. doi:10.1186/s13073-018-0553-2. PMC 5968547. PMID 29801518.[non-primary source needed]
  14. ↑ Netea, Mihai G; van de Veerdonk, Frank L; van Deuren, Marcel; van der Meer, Jos WM (August 2011). "Defects of pattern recognition: primary immunodeficiencies of the innate immune system". Current Opinion in Pharmacology. 11 (4): 412–422. doi:10.1016/j.coph.2011.03.003. PMID 21498117.[non-primary source needed]
  15. ↑ Leentjens, Jenneke; Kox, Matthijs; Koch, Rebecca M.; Preijers, Frank; Joosten, Leo A. B.; van der Hoeven, Johannes G.; Netea, Mihai G.; Pickkers, Peter (November 2012). "Reversal of Immunoparalysis in Humans In Vivo: A Double-Blind, Placebo-controlled, Randomized Pilot Study". American Journal of Respiratory and Critical Care Medicine. 186 (9): 838–845. doi:10.1164/rccm.201204-0645OC. hdl:2066/109399. PMID 22822024.[non-primary source needed]
  16. 1 2 "Prof. M.G. Netea (Mihai)". Radboud University. Retrieved 12 September 2020.
  17. 1 2 "Limes - Department of Immunology and Metabolism". LIMES-Institut, Universität Bonn. Retrieved 12 September 2020.
  18. 1 2 "Spinoza Prize for Mihai Netea". RIMLS. Retrieved 12 September 2020.
  19. ↑ Despre O istorie genetică (incompletă) a românilor at the Humanitas website]
  20. ↑ "Novel antagonists of the toll-like receptor 4". Retrieved 11 September 2020.