Mthethwa may refer to:
- Mthethwa Paramountcy, a Southern African state that arose in the 18th century south of Delagoa Bay and inland in eastern southern Africa
- Nathi Mthethwa (1967–2025), South African politician and diplomat
- Zwelakhe Mthethwa, South African politician
This disambiguation page lists articles associated with the title Mthethwa.
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