NAB1

NAB1

Identifiers

NAB1, NGFI-A binding protein 1

External IDs

OMIM: 600800; MGI: 107564; GeneCards: NAB1

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2YUF

Gene location (Human)

Chr.	Chromosome 2 (human)

Band	2q32.2	Start	190,646,746 bp
Band	2q32.2	End	190,692,766 bp

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)

Band	1 C1.1\|1 26.99 cM	Start	52,496,453 bp
Band	1 C1.1\|1 26.99 cM	End	52,539,838 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ganglionic eminence

skin of hip

skin of thigh

Achilles tendon

endothelial cell

Epithelium of choroid plexus

ventricular zone

epithelium of colon

optic nerve

tendon of biceps brachii

Top expressed in

carotid body

saccule

molar

otic placode

conjunctival fornix

calvaria

ascending aorta

skin of external ear

iris

seminal vesicula

More reference expression data


More reference expression data

Gene ontology
Molecular function	transcription factor binding transcription coregulator activity
Cellular component	nucleus
Biological process	Schwann cell differentiation myelination endochondral ossification regulation of epidermis development transcription, DNA-templated negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


4664


17936


ENSG00000138386


ENSMUSG00000002881


Q13506


Q61122

RefSeq (mRNA)


NM_005966 NM_001321312 NM_001321313 NM_001321314 NM_001321315


NM_008667

RefSeq (protein)


NP_001308241 NP_001308242 NP_001308243 NP_001308244 NP_005957


NP_032693

Location (UCSC)

Chr 2: 190.65 – 190.69 Mb

Chr 1: 52.5 – 52.54 Mb

PubMed search

View/Edit Human

View/Edit Mouse

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.

Interactions

NAB1 has been shown to interact with Zif268.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138386 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002881 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi:10.1073/pnas.92.15.6873. PMC 41432. PMID 7624335.
↑ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349. PMID 8668170.
↑ Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883. PMID 9418898.
↑ "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Thiel G, Kaufmann K, Magin A, et al. (2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3): 289–301. doi:10.1016/s0167-4781(00)00207-4. PMID 11018254.
Qiu FH, Devchand PR, Wada K, Serhan CN (2002). "Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils". FASEB J. 15 (14): 2736–8. doi:10.1096/fj.01-0576fje. PMID 11687510. S2CID 23166941.
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID 12030330. S2CID 1928229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

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