N-acetyltransferase 1

NAT1
Identifiers
Aliases	NAT1, AAC1, MNAT, NAT-1, NATI, N-acetyltransferase 1, N-acetyltransferase 1 (arylamine N-acetyltransferase)
External IDs	OMIM: 108345; MGI: 109201; GeneCards: NAT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IJA, 2PQT
Enzyme activity
Gene location (Human)
Chr.	Chromosome 8 (human)
End	18,223,689 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	67,955,236 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; mucosa of ileum; ; mucosa of colon; ; mucosa of sigmoid colon; ; epithelium of nasopharynx; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; jejunal mucosa; ; mucosa of paranasal sinus; ; mucosa of transverse colon;
	Top expressed in
	jejunum; ; fetal liver hematopoietic progenitor cell; ; duodenum; ; epithelium of stomach; ; left lobe of liver; ; ileum; ; epithelium of small intestine; ; lumbar spinal ganglion; ; left colon; ; mucous cell of stomach;
	More reference expression data
	n/a
Gene ontology
Molecular function	arylamine N-acetyltransferase activity; transferase activity; acetyltransferase activity; acyltransferase activity; N-acetyltransferase activity;
Cellular component	cytoplasm; cytosol;
Biological process	xenobiotic metabolic process; metabolism;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9
	17961
	ENSG00000171428
	ENSMUSG00000051147
	P18440; Q400J6
	P50295
NM_000662; NM_001160170; NM_001160171; NM_001160172; NM_001160173;
	NM_001160174; NM_001160175; NM_001160176; NM_001160179; NM_001291962
	NM_001168577; NM_010874
NP_000653; NP_001153642; NP_001153643; NP_001153644; NP_001153645;
	NP_001153646; NP_001153647; NP_001153648; NP_001153651; NP_001278891; NP_001153642.1; NP_001153644.1; NP_001153645.1; NP_001153646.1; NP_001153647.1
	NP_001162049; NP_035004
	Wikidata
View/Edit Human	View/Edit Mouse

N-acetyltransferase 1 (arylamine N-acetyltransferase) is a protein that in humans is encoded by the NAT1 gene.

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat NAT2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000171428 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051147 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: N-acetyltransferase 1 (arylamine N-acetyltransferase)". Retrieved 2012-01-27.

Gubin AN, Njoroge JM, Bouffard GG, Miller JL (July 1999). "Gene expression in proliferating human erythroid cells". Genomics. 59 (2): 168–77. doi:10.1006/geno.1999.5855. PMID 10409428.
Smelt VA, Upton A, Adjaye J, Payton MA, Boukouvala S, Johnson N, Mardon HJ, Sim E (April 2000). "Expression of arylamine N-acetyltransferases in pre-term placentas and in human pre-implantation embryos". Human Molecular Genetics. 9 (7): 1101–7. doi:10.1093/hmg/9.7.1101. PMID 10767335.
Brockton N, Little J, Sharp L, Cotton SC (May 2000). "N-acetyltransferase polymorphisms and colorectal cancer: a HuGE review". American Journal of Epidemiology. 151 (9): 846–61. doi:10.1093/oxfordjournals.aje.a010289. PMID 10791558.
Lo-Guidice JM, Allorge D, Chevalier D, Debuysère H, Fazio F, Lafitte LJ, Broly F (June 2000). "Molecular analysis of the N-acetyltransferase 1 gene (NAT1*) using polymerase chain reaction-restriction fragment-single strand conformation polymorphism assay". Pharmacogenetics. 10 (4): 293–300. doi:10.1097/00008571-200006000-00003. PMID 10862520.
de León JH, Vatsis KP, Weber WW (August 2000). "Characterization of naturally occurring and recombinant human N-acetyltransferase variants encoded by NAT1". Molecular Pharmacology. 58 (2): 288–99. doi:10.1124/mol.58.2.288. PMID 10908296.
Yu MW, Pai CI, Yang SY, Hsiao TJ, Chang HC, Lin SM, Liaw YF, Chen PJ, Chen CJ (November 2000). "Role of N-acetyltransferase polymorphisms in hepatitis B related hepatocellular carcinoma: impact of smoking on risk". Gut. 47 (5): 703–9. doi:10.1136/gut.47.5.703. PMC 1728099. PMID 11034589.
Wikman H, Thiel S, Jäger B, Schmezer P, Spiegelhalder B, Edler L, Dienemann H, Kayser K, Schulz V, Drings P, Bartsch H, Risch A (March 2001). "Relevance of N-acetyltransferase 1 and 2 (NAT1, NAT2) genetic polymorphisms in non-small cell lung cancer susceptibility". Pharmacogenetics. 11 (2): 157–68. doi:10.1097/00008571-200103000-00006. PMID 11266080.
Krajinovic M, Ghadirian P, Richer C, Sinnett H, Gandini S, Perret C, Lacroix A, Labuda D, Sinnett D (April 2001). "Genetic susceptibility to breast cancer in French-Canadians: role of carcinogen-metabolizing enzymes and gene-environment interactions". International Journal of Cancer. 92 (2): 220–5. doi:10.1002/1097-0215(200102)9999:9999<::AID-IJC1184>3.0.CO;2-H. PMID 11291049. S2CID 19448901.
Sekine A, Saito S, Iida A, Mitsunobu Y, Higuchi S, Harigae S, Nakamura Y (2001). "Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population". Journal of Human Genetics. 46 (6): 314–9. doi:10.1007/s100380170065. PMID 11393533.
Butler WJ, Ryan P, Roberts-Thomson IC (June 2001). "Metabolic genotypes and risk for colorectal cancer". Journal of Gastroenterology and Hepatology. 16 (6): 631–5. doi:10.1046/j.1440-1746.2001.02501.x. PMID 11422615. S2CID 37057726.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000171428 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000051147 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: N-acetyltransferase 1 (arylamine N-acetyltransferase)". Retrieved 2012-01-27.

N-acetyltransferase 1

References

Further reading