RNA cytidine acetyltransferase

NAT10
Identifiers
Aliases	NAT10, ALP, NET43, N-acetyltransferase 10, Kre33
External IDs	OMIM: 609221; MGI: 2138939; GeneCards: NAT10
Gene location (Human)
Chr.	Chromosome 11 (human)
End	34,147,670 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	103,591,615 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; skin of leg; ; skin of abdomen; ; ventricular zone; ; right ovary; ; left ovary; ; Achilles tendon; ; body of pancreas; ; tonsil; ; right uterine tube;
	Top expressed in
	spermatocyte; ; epiblast; ; neural layer of retina; ; yolk sac; ; primitive streak; ; spermatid; ; tail of embryo; ; Paneth cell; ; lens; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; acyltransferase activity; protein binding; ATP binding; N-acetyltransferase activity; tRNA binding; tRNA N-acetyltransferase activity; rRNA cytidine N-acetyltransferase activity; RNA binding; DNA polymerase binding;
Cellular component	nucleolus; membrane; nucleus; telomerase holoenzyme complex; nucleoplasm; midbody; 90S preribosome;
Biological process	rRNA processing; negative regulation of telomere maintenance via telomerase; tRNA processing; ncRNA processing; rRNA metabolic process; rRNA modification; tRNA wobble cytosine modification; tRNA acetylation; rRNA acetylation involved in maturation of SSU-rRNA; ribosomal small subunit biogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55226
	98956
	ENSG00000135372
	ENSMUSG00000027185
	Q9H0A0
	Q8K224
	NM_001144030; NM_024662
	NM_153126
	NP_001137502; NP_078938
	NP_694766
	Wikidata
View/Edit Human	View/Edit Mouse

RNA cytidine acetyltransferase, also called N-acetyltransferase 10, is an enzyme that in humans is encoded by the NAT10 gene. This enzyme functions to make N4-Acetylcytidine modifications to multiple types of RNA, including mRNAs, 18S rRNA, and tRNAs. While it has shown some protein lysine N-acetyltransferase activity in vitro, that doesn't seem to be its primary function in the body.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135372 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027185 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (November 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications. 311 (2): 506–513. Bibcode:2003BBRC..311..506L. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445.
↑ "Entrez Gene: NAT10 N-acetyltransferase 10".
1 2 "RNA cytidine acetyltransferase". Retrieved 2026-10-08.
↑ Jin G, Xu M, Zou M, Duan S (June 2020). "The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review". Molecular Therapy. Nucleic Acids. 20: 13–24. doi:10.1016/j.omtn.2020.01.037. PMC 7068197. PMID 32171170.
↑ Liu R, Wubulikasimu Z, Cai R, Meng F, Cui Q, Zhou Y, et al. (September 2023). "NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells". Nucleic Acids Research. 51 (16): 8514–8531. doi:10.1093/nar/gkad628. PMC 10484679. PMID 37497776.
↑ Tardu M, Jones JD, Kennedy RT, Lin Q, Koutmou KS (July 2019). "Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs". ACS Chemical Biology. 14 (7): 1403–1409. doi:10.1021/acschembio.9b00369. PMC 7254066. PMID 31243956.

Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (December 2000). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 7 (6): 347–355. doi:10.1093/dnares/7.6.347. PMID 11214970.
Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, et al. (November 2002). "Functional proteomic analysis of human nucleolus". Molecular Biology of the Cell. 13 (11): 4100–4109. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Liu H, Ling Y, Gong Y, Sun Y, Hou L, Zhang B (June 2007). "DNA damage induces N-acetyltransferase NAT10 gene expression through transcriptional activation". Molecular and Cellular Biochemistry. 300 (1–2): 249–258. doi:10.1007/s11010-006-9390-5. PMID 17180247. S2CID 2589666.
Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1) MSB4100134: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Chi YH, Haller K, Peloponese JM, Jeang KT (September 2007). "Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes". The Journal of Biological Chemistry. 282 (37): 27447–27458. doi:10.1074/jbc.M703098200. PMID 17631499. S2CID 44621298.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000135372 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027185 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Lv_2003-5] Lv J, Liu H, Wang Q, Tang Z, Hou L, Zhang B (November 2003). "Molecular cloning of a novel human gene encoding histone acetyltransferase-like protein involved in transcriptional activation of hTERT". Biochemical and Biophysical Research Communications. 311 (2): 506–513. Bibcode:2003BBRC..311..506L. doi:10.1016/j.bbrc.2003.09.235. PMID 14592445.

[entrez-6] "Entrez Gene: NAT10 N-acetyltransferase 10".

[uniprot-7] 1 2 "RNA cytidine acetyltransferase". Retrieved 2026-10-08.

[Jin2020-8] Jin G, Xu M, Zou M, Duan S (June 2020). "The Processing, Gene Regulation, Biological Functions, and Clinical Relevance of N4-Acetylcytidine on RNA: A Systematic Review". Molecular Therapy. Nucleic Acids. 20: 13–24. doi:10.1016/j.omtn.2020.01.037. PMC 7068197. PMID 32171170.

[Liu2023-9] Liu R, Wubulikasimu Z, Cai R, Meng F, Cui Q, Zhou Y, et al. (September 2023). "NAT10-mediated N4-acetylcytidine mRNA modification regulates self-renewal in human embryonic stem cells". Nucleic Acids Research. 51 (16): 8514–8531. doi:10.1093/nar/gkad628. PMC 10484679. PMID 37497776.

[Tardu2019-10] Tardu M, Jones JD, Kennedy RT, Lin Q, Koutmou KS (July 2019). "Identification and Quantification of Modified Nucleosides in Saccharomyces cerevisiae mRNAs". ACS Chemical Biology. 14 (7): 1403–1409. doi:10.1021/acschembio.9b00369. PMC 7254066. PMID 31243956.

RNA cytidine acetyltransferase

References

Further reading